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Flashcards in Antibiotic Quiz Deck (18)
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1
Q

What is the class and the function of penicillin?

A

b-lactams

b-lactam antibiotics inhibit transpeptidation

2
Q

What is the class and the function of vancomycin?

A

Glycoprotein

Binds to the D ala - D ala end of the peptidoglycan and inhibits crosslinking.

3
Q

What is the class and the function of cephalonsporin?

A

b-lactams

b-lactam antibiotics inhibit transpeptidation

4
Q

What is the class and the function of carbopenem?

A

b-lactams

b-lactam antibiotics inhibit transpeptidation

5
Q

What is the class and the function of monobactams

A

b-lactams

b-lactam antibiotics inhibit transpeptidation

6
Q

What is the class and the function of B-lactamase inhibitor?

A

b-lactams

this is not an antibiotic but rather a substance that prevents b lactamase from breaking down b lactam antibiotics

7
Q

What is the class and the function of tiechoplanin?

A

glycoprotein

8
Q

What is the class and the function of cyclloserine?

A

other membrane distruptor

Second line treatment for
My cobacterium tuberculosis

Cycloserine is a cyclic analog of alanine
- Also crosses blood brain
barrier and is an NMDA
receptor agonist (with
uses and side effects)
9
Q

What is the class and the function of Ioniazid and ethionamide?

A

other membrane distruptor

Inhibits Mycobacteria by affecting synthesis of mycolic acid (abundant wax in the cell wall)

10
Q

What is the class and the function of ethambutol?

A

other membrane distruptor

Inhibits Mycobacteria by affecting attachment of mycolic acid in the cell wall

11
Q

What are the six antibiotics that deal with inhibiting amino acid synthesis?

A
oxizolidiones 
tetracylcine
aminogylcosides 
chloramphenicol and lincosamides 
macrolides
12
Q

What are the four antibiotics that are associated with inhibition of nucleic acid synthesis?

A

quinolones
rifampin
rifabutin
metronidazole

13
Q

Drug Resistance: Penicillin and cephalosporins

A

plasmidborne

hydrolysis of beta lactam ring by beta lactamase

14
Q

Drug Resistance: methicillin

A

no plasmidborne

change in penicllin binding protein

15
Q

Drug Resistance: Tetracyclines

A

plasmid borne

efflux pump pushes drug out of cell

16
Q

Drug Resistance: oxizolidinomes

A

no plasmidborne

mutations in the 23srRNA

17
Q

Drug Resistance: quinolones

A

no plasmidborne

mutations in genes encoding DNA gyrase and topoisomerase IV

18
Q

Drug Resistance: plasmidborne

A

change in binding site in the peptidoglycan target (D alanine – D alanine changed to D Alanine — D lactate).