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Flashcards in antibiotic resistance Deck (11)
1

define resistance

the previously susceptible organism cannot be inhibited with clinically achievable concentrations

intermediate resistance can be treated with an increased dose

2

what is intrinsic resistance

when all strains of a species are resistant

3

what is the therapeutic index

dose needed for harm - dose needed to treat

4

describe enzymatic destruction

the drug is destroyed by subtraction or addition to the drug by an enzyme

5

name some resistance mechanisms

efflux
impermeability
alternative pathway
altered binding site

6

what does alternative pathway mean

the bacteria finds a different way to synthesise the molecule

7

what does alternative binding site mean

the binding site on the enzyme which the drug normally inhibits is changed so the drug cannot bind

8

describe quinolone resistance

single point mutation gives low level resistance
2 point mutations give high level resistance
gemifloxacin is active against both mutants (dual targeting)

9

what are 3 ways that mutations can be shared

transposons and integrons
conjugation
transformation

10

what is a superbug

an organism that has gained resistance to critical or multiple antibiotics

11

how are resistant bugs treated

culture
susceptibility testing
use the most bactericidal drug available
consider combinations