Antibiotic resistance Flashcards Preview

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Flashcards in Antibiotic resistance Deck (10):
1

What are the 6 main targets of antibiotics?

1-Cell wall synthesis
2-RNA synthesis
3-Amino-acyl-tRNA synthetase
4-Folic acid (tetrahydrofolate) synthesis)
5-Protein Synthesis
6-DNA replication/repair/segregation

2

What are 4 ways bacteria gain resistance to antibiotics?

1-restrict access of antibiotic to target (efflux pumps)
2-Modify the target
3-Enzymatic inactivation or modification of antibiotic
4-Modify expression of bacterial factors needed to activate the antibiotic-prodrugs

3

How do bacteria become resistant to tetracycline?

altering the 16S rRNA involved in tetracycline binding of the 30S subunit

4

What drug resistance is an example of multistep process resistance?

Vancomycin

5

How do bacteria develop resistance to aminoglycosides?

modifications that disrupt hydrogen-bonding network used to bind 16S rRNA

6

A dormant cell that is resistant to many stresses and antibiotic treatments is called?

Persister cell

7

Which two spore-forming bacteria are persistent in the environment and are common with IV drug users?

C. Tetani, B anthracis

8

Which spore former causes gas gangrene?

C. Perfringens

9

Which 3 spore-formers cause food-borne infections?

1-C. Botulinum
2-C. Perfringens
3-B. Cereus

10

Which spore former is a responsible for nosocomial infections?

Clostridrium difficle

*overgrowth causes pseudomembranous colitis