Antibiotics Flashcards Preview

Integrative Week One > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (46):
1

Pencillin Uses

Group A strep
confirmed pneumococcal (pneumonia, meningitis)
Meningococcal infection
syphilis

2

Amp/Amox

acute sinusitis, otitis
pneumo, Hflu, Moraxella
Listeria (amp)
~ Enterococcus

3

Bronchitis

don't treat with antibiotics unless hosp. COPD pt

4

Augmentin

amox + beta-lactam inhib
peristent minor infections

5

Unasyn

Amp + beta-lactam inhibitor
mixed infections

6

Ticarcillin/Piperacillin

Anti-pseudomonas
- burn pts
- neutropenic
-HAP
- CF

7

Timentin

Ticarcillin + beta lactamase inhibitor

8

Zosyn

Piperacillin + beta lactamase inhibitor
not for serious pseudomonal infections

9

IV Nafcillin

S. aureus (cellulitis, endocarditis)

10

IV Oxacillin

S. aureus (cellulitis, endocarditis)

11

Dixcloxacillin

oral S. Aureus

12

Cephalosporins - general

don't cover Enterococcus
most don't cover anaerobes

13

1st generation cephalosporins

better gram+
less gram -

14

3rd generation cephalosporins

better gram -
less gram +

15

Cefazolin

1st generation, IV
minor staph infections (outpatient cellulitis)
pre-op prophylaxis

16

Cefuroxime

2nd generation, IV
persistent minor infections (otitis, etc)
similar to Augmentin

17

3rd generation Ceph uses

serious gram neg infections (sepsis)
all types of meningitis

18

Ceftazidime

anti-pseudomonas
but induces beta lactamase

19

Cefixime

can cause bright red stools (warn patients)

20

Cefepime

anti-pseudomonal
not approved for children <2 mon

21

Ceftriaxone

IM, great for gonorrhea

22

Aminoglycosides

block protein synthesis at 30S ribosomal unit
Gram neg infections!!
Gentamicin < Tobramycin < Amikacin

23

Aminoglycoside uses

Gram neg
often treated with 2 drugs
synergistic with Beta lactams
don't use in pneumonia, meningitis

24

Aminoglycoside side effects

ototoxicity
nephrotoxicity

25

Macrolides

bind to 50S ribosome unit
bacteriostatic
erythomycin, azithromycin, clarithomycin

26

Macrolide uses

gram+, gram + (no anaerobes)
mycoplasma
legionella

27

Azithromycin

less side effects
second choice for Chlamydia

28

Chlyamdia treatment

Doxycycline
Azithromycin

29

TMP-SMX

block nucleotide synthesis by inhibiting bacterial folate synthesis

30

TMP-SMX uses

gram + gram -
minor infections: otitis, sinusitis
uncompliated UTI/cystitis
pneumocystitis jiroveci
non serious soft tissue MRSA infections
not for strep throat, pseudomonas, anaerobes

31

TMP-SMX side effects

Rash, Steven Johns
hemolysis with G6PD def

32

Tetracyclines

inhibit 30s ribosomal subunit
Doxycycline

33

Doxycycline

Chlamydia
atypical pneumonas (Chlaymdia, Mycoplasma)
pneumococcus
Rickettsiae dz (RMSF)

34

Nitrofurantoin

safe during pregnancy
cause use irreversible pulmonary interstitial disease

35

Doxycycline side effects

photosensitivity
teeth staining

36

Quinolones

inhibit DNA gyrase, topoisomerases
Ciprofloxacin

37

Ciprofloxacin

broad spectrum
kills everything except Pneumococcus

38

Ciprofloxacin side effects

achilles tendon rupture
neuromuscular blocking activity

39

Clindamycin

lincosamide
blocks 50S

40

Metronidazole

promotes free radicals which damage bacteria DNA
anaerobic infections
C diff, Trichomonas, Giardia

41

Vancomycin

inhibits cell wall synthesis and peptidoglycan synthensis

42

Vancomycin use

great staph coverage, reserve for MRSA
C diff

43

Aztreneoam

for serious infections
use in PCN allergic patients

44

Carapenams/Primaxin

IV drug for serious infections
ESBL gram neg

45

Linezolid

anti-VRE and MRSA
periperal neuropathy and myelosuppression, MAO inhibitor

46

Daptomycin

ANTI-VRE and MRSA
MRSA skin infections, bacteremia, endocarditis but NOT pneumonia