Antibiotics Flashcards Preview

Pharmacology I > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (28):
1

Four mechanisms of action for Antibiotics

1. Inhibits cell wall synthesis

2. Inhibits translation and transcription (Protein)

3. Inhibits DNA synthesis and integrity

4. Inhibits folate synthesis and function

2

What is the post antibiotic effect?

Suppression of bacterial growth after being exposed to antimicrobial agent

3

Clinical use for 1st generation Cephalosporins?

Skin, soft tissues, UTI's

Cross-sensitivity with penicillin-dangerous for penicillin allergic pos

4

Use of 2nd Gen. Cephaosporins?

S. pneumonia
H. influenza
B. fragailits (cefotetan0

5

Use of 3rd Gen Cephalosporins use

Pneumonia, meningitis (CNS), and gonorrhea

Broad activity, B-lacamase-stable

6

4th Gen Cephalosporins use?

Pseudomonas coverage

7

5th Gen Cephalosporins use?

Skin, soft
CAP

8

Name Peniciilinase-susceptable drugs and their clinical use?

Penicillin G or K

Narrow spectrum that treats Stept throat (pyogenes)

9

What are the ADE of Penicillins?

- Hypersensitivity rx

- Maculopapular rash

10

Name Peniciilanse-resistant drugs?

Nafcillin

11

Wider spectrum penicillin drugs?

Amoxicillin- useful for H. Influenza

12

What are ADEs for Cephalosporins?

First generation cross-reactivity with penicillins- concern for allergic patients

13

What are Carbapenems useful for?

-Pencillin RSP strains

-Gram neg rods

-Pseudomonas sp

14

What are Monobactams useful for?

Gram negative bacteria

Also there is no cross=allergenicity with beta-lactams

15

ADE of Tetracylines

Deposites in developing bones and teeth

16

Prototype for Macrolides

Azithromycin (Z-pack)

17

What are the ADE of Macrolides

GI upset
Hepatic dysfunction
QT elongation
CYP450 inhibition (except Azithromycin)

18

Prototype for Lincosamides

Clindamycin

19

What is Clindamycin ADE's

Can cause C. difficile colitis

20

What is Chloramphicol useful for?

slide 33

21

Prototype for oxazolidinone?

Activity against what?

Liezolid

MRSA
PRSP
VRE strains

22

ADE's of Linezolid

Dose related anemia
Neuropathy
Optic neuritis

Serotonin Syndrome with SSRI

23

Prototype for Aminoglycosides

Gentamicin

Tobramycin

24

ADE's for Aminoglycosides

Nehprotoxicity
Ototoxicity (irreversible)
Neuromuscular blockade

25

Quinilones prototype and naming clue?

"floxacin"

Ciprofloxacin
Levofloxacin

26

What is Empiric Treatment

Use of antibiotic before pathogen is identified

27

Guided Treatment

slide 42

28

What is an Antiobiogram? How is it used

Report of susceptibility/resistance of pathogens to antibiotics

Can be used to determine empiric treatment options