Antibiotics (Antiprotozoal Drugs -- Antimalarial Drugs) Flashcards Preview

P Pha T > Antibiotics (Antiprotozoal Drugs -- Antimalarial Drugs) > Flashcards

Flashcards in Antibiotics (Antiprotozoal Drugs -- Antimalarial Drugs) Deck (10):
1

ANTIMALARIAL DRUGS
______________
- prevents polymerization of heme (toxic to parasites) into hemozoin; blood schizonticide
- may precipitate porphyria

ANTIMALARIAL DRUGS
Chloroquine
- prevents polymerization of heme (toxic to parasites) into hemozoin; blood schizonticide
- may precipitate porphyria

2

ANTIMALARIAL DRUGS
_____________
- complexes with ________ to prevent strand separation; blocks DNA replication and transcription; blood schizonticide
-used for chloroquine-resistant malaria
- DOC for malaria in pregnant patients
- SE: ____________ (headache, tinnitus, vertigo), _________________ (severe complication of P. falciparum malaria; characterized by intravascular hemolysis, massive hemoglobinuria and acute renal failure)
- commonly used with ____________ or _____________ to limit toxicities

ANTIMALARIAL DRUGS
Quinine
- complexes with DNA to prevent strand separation; blocks DNA replication and transcription; blood schizonticide
-used for chloroquine-resistant malaria
- DOC for malaria in pregnant patients
- SE: cinchonism (headache, tinnitus, vertigo), blackwater fever (severe complication of P. falciparum malaria; characterized by intravascular hemolysis, massive hemoglobinuria and acute renal failure)
- commonly used with doxycycline or clindamycin to limit toxicities

3

ANTIMALARIAL DRUGS
_______________
- blood schizonticide
- for chemoprophylaxis (chloroquine-resistant areas); alternative to quinine on acute attacks of falciparum malaria

ANTIMALARIAL DRUGS
Mefloquine
- blood schizonticide
- for chemoprophylaxis (chloroquine-resistant areas); alternative to quinine on acute attacks of falciparum malaria

4

ANTIMALARIAL DRUGS
______________
- forms electron-transferring redox compounds that act as cellular oxidants; tissue schizonticide; gametocide
- SE: methemoglobinemia
- should be used with a blood schizonticide; eradicates hypnozoites in the liver, preventing malarial relapse

ANTIMALARIAL DRUGS
Primaquine
- forms electron-transferring redox compounds that act as cellular oxidants; tissue schizonticide; gametocide
- SE: methemoglobinemia
- should be used with a blood schizonticide; eradicates hypnozoites in the liver, preventing malarial relapse

5

ANTIMALARIAL DRUGS
Atovaquone-Proguanil
- _____________ disrupts electron transport; blood and tissue schizonticide
- ___________ inhibits folate synthesis; sporonticide
- for chloroquine-resistant P. falciparum

ANTIMALARIAL DRUGS
Atovaquone-Proguanil
- Atovaquone disrupts electron transport; blood and tissue schizonticide
- Proguanil inhibits folate synthesis; sporonticide
- for chloroquine-resistant P. falciparum

6

ANTI-MALARIAL DRUGS
Sulfadoxine-pyrimethamine
- MOA: sequential blockade of folic acid synthesis; blood schizonticide. Sporonticide (____________)
- for chloroquine-resistant P. falciparum

ANTI-MALARIAL DRUGS
Sulfadoxine-pyrimethamine
- MOA: sequential blockade of folic acid synthesis; blood schizonticide. Sporonticide (pyremithamine)
- for chloroquine-resistant P. falciparum

7

ANTI-MALARIAL DRUGS
________________
- impairs progeny of malarial apicoplast genes, resulting in abnormal cell division; blood schizonticide
- for chemoprophylaxis of multidrug-resistant malaria
- do not drink with ______ (decreased absorption)

ANTI-MALARIAL DRUGS
Doxycycline
- impairs progeny of malarial apicoplast genes, resulting in abnormal cell division; blood schizonticide
- for chemoprophylaxis of multidrug-resistant malaria
- do not drink with milk (decreased absorption)

8

ANTIMALARIAL DRUGS
____________
- blood schizonticide
- for chloroquine-resistant malaria and sever falciparum malaria
SimD: lumefantrine

ANTIMALARIAL DRUGS
Halofantrine
- blood schizonticide
- for chloroquine-resistant malaria and sever falciparum malaria
SimD: lumefantrine

9

ANTIMALARIAL DRUGS
______________
- forms toxic free radicals in malarial food vacuole
NOTE:_______________________ is the DOC for uncomplicated falciparum malaria in the Philippines

ANTIMALARIAL DRUGS
Artemisinin
- forms toxic free radicals in malarial food vacuole
NOTE: Co-artem (lumefantrin-artemisinin) is the DOC for uncomplicated falciparum malaria in the Philippines

10

MALARIA PROPHYLAXIS
For chloroquine-sensitive areas:
-- chloroquine
For chloroquine-resistant areas:
-- __________
-- __________
For multi-drug resistant areas:
-- __________
For terminal prophylaxis of P vivax and P ovale infections (to prevent relapse)
-- primaquine (tissue schizonticide)

MALARIA PROPHYLAXIS
For chloroquine-sensitive areas:
-- chloroquine
For chloroquine-resistant areas:
-- mefloquine
-- malarone
For multi-drug resistant areas:
-- doxycycline
For terminal prophylaxis of P vivax and P ovale infections (to prevent relapse):
-- primaquine (tissue schizonticide)

Decks in P Pha T Class (62):