Antibiotics (Cell Wall Synthesis Inhibitors) Flashcards Preview

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Flashcards in Antibiotics (Cell Wall Synthesis Inhibitors) Deck (17):
1

A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin
1) penicillin G / benzyl penicillin
2) penicillin V
3) methicillin
4) oxacillin
5) nafcillin
6) cloxacillin
7) ampicillin
8) amoxicillin
9) ticarcillin
10) carbenicillin
11) piperacillin


1) penicillin G / benzyl penicillin (IV) - A
2) penicillin V (oral) - A
3) methicillin - B
4) oxacillin - B
5) nafcillin - B
6) cloxacillin - B
7) ampicillin (IV) - C
8) amoxicillin (oral) - C
9) ticarcillin - D
10) carbenicillin - D
11) piperacillin - D

Antipseudomonal penicillins mnemonic:
Takes Care of Pseusomonas: Ticarcillin, Carbenicillin, Piperacillin

2

Used for streptococcal, pneumococcal, meningococcal infections; syphilis
A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

Natural penicillin

3

Used for staphylococcal infections
A. Natural penicillin
B. Isoxazolyl penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

Isoxazolyl

4

Used for infections due to Moraxella catarrhalis, and HELPSE (Haemophilus influenzae, E. coli, Listeria monocytogenes, Proteus mirabilis, Salmonella spp., Enterococci)
A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

Amino penicillin

5

Used for infections due to PEK (Pseudomonas, Enterobacter, and Klebsiella)
A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

Antipseudomonal penicillin

6

Renal tubular reabsorption inhibited by probenecid
A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

A

7

Inactivated by beta-lactamase
A. Natural penicillin
B. Isoxazolyl / antistaphylococcal penicillin
C. Amino / extended spectrum penicillin
D. Antipseudomonal penicillin

A, C, D

8

Beta-lactamase resistant antibiotics: (3)

Anti-staphylococcal penicillins, fourth generation cephalosporins, aztreonam (a monobactam)

9

MNEMONICS for CEPHALOSPORINS

1st gen:
all ceph-
cefazolin and cefadroxil

2nd gen:
all cef- not ending with -ime and -one except ____________
all those ending with -_____
____________

3rd gen:
those ending with -ime or -one except cefuroxime
ceftibuten, ceftitoren, cefdinir
___________

4th gen: __________, __________

MNEMONICS for CEPHALOSPORINS

1st gen:
all ceph-
cefazolin and cefadroxil

2nd gen:
all cef- not ending with -ime and -one except ceforoxime
all those ending with -ole
loracarbef

3rd gen:
those ending with -ime or -one except cefuroxime
ceftibuten, ceftitoren, cefdinir
moxalactam

4th gen: cefepime, ceftaroline

10

Anti-pseudomonal cephalosporins (3)

Ceftazidime
Cefepime
Cefoperazone

11

Imipenen-Cilastatin
- Cilastatin inhibits ____________ of imipenem

renal metabolism

12

Monobactam with no activity against gram-positive bacteria or anaerobes

Aztreonam

13

Glycopeptide which inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan
Used for MRSA, pseudomembranous colitis (not first line)
SE: Red man syndrome (secondary to histamine release; treat by slowing the rate of infusion)

Vancomycin

14

Peptide antibiotic for gram-positive bacteria reserved for topical use due to marked nephrotoxicity

Bacitracin

15

Antimetabolite which blocks incorporation of D-Ala into the pentapeptide side chain of the peptidoglycan
Used for drug-resistant tuberculosis (2nd line)

Cycloserine

16

Inactivates UDP-N-acetylglucosamine-3-enolpyruvyltransferase which is important inpeptidoglycan synthesis; safe for pregnant patients

Fosfomycin

17

DOC for typhoid fever

Ceftriaxone

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