Antibiotics Lecture 28

Question 1

Penicillin G, V
MOA
Cidal or static 
Clinical Use
Toxicity
Resistance

Answer 1

Bind Penicillin-binding proteins, block transpeptidase cross linking of peptidoglycan in cell wall
Time Dependent Killing

1. Mostly Gram Positive
2. Gram Negative cocci
   - N. spp
3. Spirochetes
   - T. Pallidum(Syphilis) **

Toxicity:

• Hypersensitivity reactions
• Hemolytic anemia

Penicillinase in bacteria

Question 2

Penicillinase-SENSITIVE penicillins
Drugs
Clinical Use
Toxicity

Answer 2

Amoxicillin, Ampicillin
Gram Positive
- Enterococcus
- Listeria

Gram negative
- Proteus mirabilis
- E. coli
- Salmonella
- Shigella
- H. flu 
HELPSS 

Toxicity:

1. Hypersensitivity; rash
2. Pseudomembranous colitis

Question 3

Penicillinase-resistant penicillins
MOA
Drugs 
Clinical Use
Toxicity

Answer 3

-bulky group blocks b-lactamases
-Dicloxacillin, nafcillin, oxacillin
MSSA

Toxicity:

1. Hypersensitivity
2. Interstitial Nephritis

Question 4

Carboxypenicillins
Drug
Clinic

Answer 4

anti pseudomonal

Question 5

Ureidopenicillins
Drug
Clinic

Answer 5

anti pseudomonal + anaerobes