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Flashcards in Antibiotics (Overview) Deck (6):
1

Bactericidal or bacteriostatic?
1) tetracycline
2) chloramphenicol
3) clarithromycin
4) clindamycin
5) linezolid
6) sulfonamide
7) trimethoprim
8) pyrimethamine
9) ethambutol
10) dapsone

All are bacteriostatic.

MNEMONIC for bacteriostatic antibiotics: PADE
Protein synthesis inhibitors except aminoglycosides and streptogramins
Antimetabolites when used alone
Dapsone
Ethambutol

2

Which antibiotics are considered drugs of last resort? (6)

I AM your Last Shot for Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin

3

For antibiotics, if they have something to do with the CYP450 enzymes, they are always inhibitors except for _________ and __________

griseofulvin
rifampin

4

DOC for Mycobacterium avium intracellular complex (MAC)

Erythromycin

5

All macrolides inhibit CYP450 enzymes except ___________.
This also has the highest Vd and slowest elimination of all macrolides.

azithromycin

6

MODES OF ANTIBACTERIAL ACTION

Concentration-Dependent Killing Action
- as the plasma level is increased above the MIC, an increasing proportion of bacteria are killed and at a more rapid rate
- e.g. ______________

Time-dependent Killing Action
- Efficacy is directly related to time above MIC
- Efficacy is independent of concentration once the MIC has been reached
- e.g. Penicillins, cephalosporins

MODES OF ANTIBACTERIAL ACTION

Concentration-Dependent Killing Action
- as the plasma level is increased above the MIC, an increasing proportion of bacteria are killed and at a more rapid rate
- e.g. Aminoglycosides

Time-dependent Killing Action
- Efficacy is directly related to time above MIC
- Efficacy is independent of concentration once the MIC has been reached
- e.g. Penicillins, cephalosporins

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