Antibody Disorders Flashcards Preview

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Flashcards in Antibody Disorders Deck (16):
1

Heart defects, hypocalcemia and absence of a thymic shadow on CXR, what are these symptoms associated with?

DeGeorge Syndrome

2

Which immune deficiencies are most common

3

Which are more common? Primary or seconday immunodeficiencies

Secondary

4

How did she describe antigen presentation differently in terms of B cells and T cells

5

In what order can the antibodies be made in terms of the ordering of the gene segments

[IgM]

6

What is memory antibody

IgG

7

Clinical patterns of immune deficiencies

1. Lymphoid tissue or nasal polyps

2. Eczema, cutaneous non-healing lesions, rashes

3. Hepatorsplenomaegaly

8

 Why do we do a UA test in patients suspected of being immunodeficient

Kidneys might be damaged, they may allow proteins to leave in the urine, leading to low immunoglobulins levels in the blood

9

Arthralgia

Joint pain

10

 Selective IgA deficiency

1. Complete absence of IgA (has to be complete, which is less than 6).

2. IgA reaches adult levels around the time of puberty

3. The rest of the immune system and Igs are normal

4. Patients also have autoimmune disease

5. Patients also have allergies like asthma or food allergies

11

Prophylactic treatment

Actions taken to prevent a disease. In the case of IgA deficiency we give low doses of antibiotics daily or three times a week to the patient

12

What disease is associated with scarring of the bronchus (bronchiectasis)

Commonvariable Immunodeficiency (CVID) and CF

13

CVID

14

CVID clinical presentation

Part of the immune system is overactive resulting in autoimmunity and the other part of the immune system is underactive resulting in low levels of IgG, IgA and/or IgM

15

What is the treatment for CVID 

IVIG and subcutaneous (SC) IG (these are patches that gives Ig through the skin)

16

SADNI (Specific Antibody Deficiency with Normal Immunoglobulin) and how is it treated

Patients dont make antibodies in reponse to a specific vaccine, which is evaluated after 4 weeks.

IVIG and antibiotics