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MS1 - Blood & Lymph > Antibody Genes > Flashcards

Flashcards in Antibody Genes Deck (9)
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1

Cross-reactivity refers to ____________.

the ability of one antibody to react to more than one antigen (sometimes with similar amino acid sequences and sometimes not--with similar charge/hydrophilicity distributions)

2

A toxoid is a substance _________.

whose toxicity has been negated by chemical addition but whose immogenicity is still intact

3

Affinity maturation is _________.

the process by which antibodies become more matched to their antigen by slight modifications

4

Describe the process behind rheumatic heart disease.

Laminin (found in heart valves) cross-reacts with group A streptococci. When antibody is made for group A strep, it can then bind to laminin sufficiently enough to produce symptoms.

5

The variable region of the heavy chain expresses ______, while the variable region of the light chain expresses only ____.

VDJ; VJ

6

In a heavy chain, ___ first joins with ____ before the complex joins with _____.

D; J; V

7

Constant regions are ________.

spliced out of the primary mRNA transcript

8

The enzymes that initiate recombination of B cell genes are called _______.

RAG-1 and RAG-2 (lack of which occurs in Omenn syndrome)

9

What is the N region?

The region where VDJ segments join (so between V and DJ as well as D and J).

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