Flashcards in Antibody Genes Deck (9)
Cross-reactivity refers to ____________.
the ability of one antibody to react to more than one antigen (sometimes with similar amino acid sequences and sometimes not--with similar charge/hydrophilicity distributions)
A toxoid is a substance _________.
whose toxicity has been negated by chemical addition but whose immogenicity is still intact
Affinity maturation is _________.
the process by which antibodies become more matched to their antigen by slight modifications
Describe the process behind rheumatic heart disease.
Laminin (found in heart valves) cross-reacts with group A streptococci. When antibody is made for group A strep, it can then bind to laminin sufficiently enough to produce symptoms.
The variable region of the heavy chain expresses ______, while the variable region of the light chain expresses only ____.
In a heavy chain, ___ first joins with ____ before the complex joins with _____.
D; J; V
Constant regions are ________.
spliced out of the primary mRNA transcript
The enzymes that initiate recombination of B cell genes are called _______.
RAG-1 and RAG-2 (lack of which occurs in Omenn syndrome)