Antibody Structure and Function Flashcards Preview

Immunology > Antibody Structure and Function > Flashcards

Flashcards in Antibody Structure and Function Deck (14):
1

What antibody exists in two forms?

IgA, secretory form and non-secreted form

2

What is the structure of antibody?

two light chains, two heavy chains

3

Which antibody has the shortest half life?

IgE

4

Which antibodies neutralize?

IgG, IgA

5

What antibody opsonizes?

IgG

6

What antibodies activate complement?

IgM, IgG

7

What antibody transports across epithelium (to gut, resp tract, urinary tract, mother's milk)?

IgA

8

What antibody can transport across the placenta?

IgG

9

Can IgM participate in opsonization? Why or why not?

No, not without complement because immune cells do not have IgM receptors

10

What antibodies have a J chain?

IgM (pentamer joined by J chain), IgA secretory form

11

What is the T piece?

The secretory piece of IgA, resists acid hydrolysis

12

What does papain digest?

yields three fragments, 2 Fab, 1 Fc
cleaves the interchain disulfide bonds

13

What does pepsin digest?

yields 2 fragments, 1 F(ab)2, 1 Fc

14

What two regions are in the variable region of Ab?

framework residues, hypervariable region