Anticancer Flashcards Preview

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Flashcards in Anticancer Deck (19):
1

Mechlorethamine

Mechanism: Alkylating agents, DNA synthesis inhibitor
CCNS

Main Toxicity:
Nausea, vomiting
bone marrow depression

2

Cyclophosphamide

Mechanism: Alkylating agents, DNA synthesis inhibitor, CCNS, activation in the liver

Main Toxicity:
Nausea, vomiting
bone marrow depression

3

Carmustine

Mechanism: Alkylating agent, CCNS, Lipid soluble (good for brain tumors)

Main Toxicity:
Nausea, vomiting
bone marrow depression

4

Cisplatin

Mechanism: Alkylating agent, CCNS

Main Toxicity:
Nausea, vomiting
bone marrow depression
*Nephrotoxicity and ottotoxicity

5

Methotrexate

Mechanism: antimetabolite, S-phase, (inhibitor of dihydrofolate reductase)

Main Toxicity:
Nausea, vomiting
bone marrow depression

6

Mercaptopurine

Mechanism: antimetabolite, purine analog, S-phase

Main Toxicity:
Nausea, vomiting
bone marrow depression

7

Fluorouracil

Mechanism: pyramidine analog, antimetabolite, S-Phase

Main Toxicity:
Nausea, vomiting
bone marrow depression

8

Cytarabine

Mechanism: pyrimidine analog, antimetabolite, S phase

Main Toxicity:
Nausea, vomiting
bone marrow depression

9

Daunorubicin hydrochloride

Mechanism: intercalates and binds DNA, CCNS

Main Toxicity:
Nausea, vomiting
bone marrow depression
Cardiotoxic

10

Doxorubicin hydrocholride

Mechanism: intercalates and binds DNA, CCNS

Main Toxicity:
Nausea, vomiting
bone marrow depression
Cardiotoxic

11

Vinblastine sulfate

Mechanism: binds tubulin prevents metaphase, mitosis arrest, M phase

Main Toxicity:
Nausea, vomiting
bone marrow depression
*Neurological toxicity

12

Vincristine sulfate

Mechanism: disrupt mitosis spindle, Mitosis arrest, M Phase

Main Toxicity:
Nausea, vomiting
bone marrow depression
*Neurological toxicity

13

Etoposide

Mechanism: Topoisomerase inhibitor, breaks DNA, G2-phase

Main Toxicity:
Nausea, vomiting
bone marrow depression

14

Paclitaxel

Mechanism: antimicrotubule agent, promotes microtubule assembly, G2+M

Main Toxicity:
Nausea, vomiting
bone marrow depression

15

Prednisone

Mechanism: increase PMNs, decrease mitosis in lymphocytes

Main Toxicity:
Short= none
Long= Cushing’s syndrome, osteoporosis, infections, ulcers

16

Dexamethasone

Mechanism: increase PMNs, decrease mitosis in lymphocytes

Main Toxicity:
Short= none
Long= Cushing’s syndrome, osteoporosis, infections, ulcers

17

Tamoxifen

Mechanism: anti estrogen,

Main Toxicity:
Short=hot flashes, nausea, vomiting
*menopasual sum
Long= visual disturbances, hypercalcemia, vaginal bleeding

18

Imatinib

Mechanism: bcr-abl protein Tyrosine kinase inhibitor, cell proliferation inhibition and induction of apoptosis

Main Toxicity:
Short= abdominal pain, nausea, vomiting, diarrhea,
Long= fatigue,edema, joint pain, fluid retention, cramps, rash

19

Trastuzumab

Mechanism:binds HER-2 (decrease EGF signaling, decrease metastatic potential), G1 Cell cycle arrest

Main Toxicity:
Short= N/V/D
Long=anemia, neutropenia, infections, fatigue, infusion rxn, and rash
*Breast cancer