Anticancer Drugs

Question 1

Antimetabolites

Answer 1

5-Fluorouracil
Methotrexate
Gemcitabine
6-mercaptopurine

Question 2

Antitumor antibiotics

Answer 2

Bleomycin
Doxorubicin
Mitomycin

Question 3

Acts on G2 phase

Answer 3

Bleomycin

Question 4

Acts on M phase

Answer 4

Mnemonic: MVP
M phase
Vinblastine
Vincristine
Paclitaxel

Question 5

Cell cycle non specific

Answer 5

Alkylating agents

Antitumor antibiotics

Question 6

Rescue therapy for cyclosphamide

Answer 6

Mesna

Question 7

Rescue therapy for cisplatin

Answer 7

Amifostine

Question 8

Rescue therapy for methotrexate

Answer 8

Leukovorin

Question 9

Rescue therapy for doxorubicin

Answer 9

Dexrazoxane

Question 10

Used for CML

Answer 10

Busulfan

Question 11

MOA of methotrexate

Answer 11

Inhibits dihydrofolate reductase

Question 12

Used for ALL and AML

Answer 12

6-mercaptopurine
Cytarabine
Vincristine

Question 13

Most specific for the S phase of the cell cycle

Answer 13

Cytarabine

Question 14

Used for pancreatic ca

Answer 14

Gemcitabine

Question 15

Used for metastatic colorectal ca

Answer 15

Irinotecan

Question 16

Prevents microtubule assembly (M phase)

Answer 16

Vincristine

Vinblastine

Question 17

Prevents microtubule disassembly

Answer 17

Paclitaxel

Question 18

Used for advanced breast and ovarian ca

Answer 18

Paclitaxel

Question 19

Most specific for the G2 phase

Answer 19

Bleomycin

Question 20

Used for Wilm’s tumor

Answer 20

Actinomycin D

Question 21

Used in CML and GIST

Answer 21

Imatinib

Question 22

Used for metastatic breast ca

Answer 22

Transtuzumab

Question 23

Inhibits angiogenesis (VEGF); used for DM retinopathy (proliferative)

Answer 23

Bevacizumab

Question 24

Used for hairy cell leukemia

Answer 24

Interferon-alpha

Question 25

Used for APML

Answer 25

All-trans retinoic acid

Question 26

Used for adrenal suppression

Answer 26

Prednisone

Question 27

Used for hormone-responsive breast ca (ER- and PR- positive)

Answer 27

Tamoxifen

Question 28

Alkylating agents

Answer 28

Cyclophosphamide | Cisplatin

Question 29

Used for breast cancer which express HER-2/neu receptor

Answer 29

Trastuzumab

Question 30

Causes cardiomyopathy

Answer 30

Doxorubicin

Question 31

Causes peripheral neuropathy

Answer 31

Vincristine

Question 32

Used for testicular cancer

Answer 32

PEB regimen: Cisplatin Etoposide Bleomycin

Question 33

Used for Hodgkin Lymphoma

Answer 33

``` MOPP regimen: Mechlorethamine Vincristine Prednisone Procarbazine ```

Question 34

Used for Non-Hodgkin's lymphoma

Answer 34

``` CHOP regimen: Cyclophosphamide Doxorubicin Vincristine Prednisone + Rituximab ```

Question 35

Used for colon cancer

Answer 35

5-FU + leucovorin + oxaliplatin

Question 36

Used for ovarian cancer

Answer 36

Paclitaxel and Carboplatin

Question 37

Used for lung cancer

Answer 37

Carboplatin, paclitaxel, and bevacizumab