Anticancer Drugs Flashcards Preview

Pharmacology > Anticancer Drugs > Flashcards

Flashcards in Anticancer Drugs Deck (37)
1

Antimetabolites

5-Fluorouracil
Methotrexate
Gemcitabine
6-mercaptopurine

2

Antitumor antibiotics

Bleomycin
Doxorubicin
Mitomycin

3

Acts on G2 phase

Bleomycin

4

Acts on M phase

Mnemonic: MVP
M phase
Vinblastine
Vincristine
Paclitaxel

5

Cell cycle non specific

Alkylating agents
Antitumor antibiotics

6

Rescue therapy for cyclosphamide

Mesna

7

Rescue therapy for cisplatin

Amifostine

8

Rescue therapy for methotrexate

Leukovorin

9

Rescue therapy for doxorubicin

Dexrazoxane

10

Used for CML

Busulfan

11

MOA of methotrexate

Inhibits dihydrofolate reductase

12

Used for ALL and AML

6-mercaptopurine
Cytarabine
Vincristine

13

Most specific for the S phase of the cell cycle

Cytarabine

14

Used for pancreatic ca

Gemcitabine

15

Used for metastatic colorectal ca

Irinotecan

16

Prevents microtubule assembly (M phase)

Vincristine
Vinblastine

17

Prevents microtubule disassembly

Paclitaxel

18

Used for advanced breast and ovarian ca

Paclitaxel

19

Most specific for the G2 phase

Bleomycin

20

Used for Wilm's tumor

Actinomycin D

21

Used in CML and GIST

Imatinib

22

Used for metastatic breast ca

Transtuzumab

23

Inhibits angiogenesis (VEGF); used for DM retinopathy (proliferative)

Bevacizumab

24

Used for hairy cell leukemia

Interferon-alpha

25

Used for APML

All-trans retinoic acid

26

Used for adrenal suppression

Prednisone

27

Used for hormone-responsive breast ca (ER- and PR- positive)

Tamoxifen

28

Alkylating agents

Cyclophosphamide
Cisplatin

29

Used for breast cancer which express HER-2/neu receptor

Trastuzumab

30

Causes cardiomyopathy

Doxorubicin

31

Causes peripheral neuropathy

Vincristine

32

Used for testicular cancer

PEB regimen:
Cisplatin
Etoposide
Bleomycin

33

Used for Hodgkin Lymphoma

MOPP regimen:
Mechlorethamine
Vincristine
Prednisone
Procarbazine

34

Used for Non-Hodgkin's lymphoma

CHOP regimen:
Cyclophosphamide
Doxorubicin
Vincristine
Prednisone
+
Rituximab

35

Used for colon cancer

5-FU + leucovorin + oxaliplatin

36

Used for ovarian cancer

Paclitaxel and Carboplatin

37

Used for lung cancer

Carboplatin, paclitaxel, and bevacizumab