Anticoagulants

Question 1

What is anticoagulation therapy indicated for?

Answer 1

prophylaxis and treatment of venous thromboembolism

Question 2

What are rivaroxaban and dabigatran contraindicated in?

Answer 2

• renal insufficiency
• when taken in combination with strong inhibitors of CYP3A4 and P-glycoprotein

Question 3

What are low molecular weight heparins contraindicated in?

Answer 3

• patients with a history of heparin induced thrombocytopenia (HIT)
• should be used with caution in patients with renal dysfunction

Question 4

What is unfractionated heparin contraindicated in?

Answer 4

patients with a history of heparin induced thrombocytopenia (HIT)

Question 5

What is warfarin contraindicated in?

Answer 5

• pregnancy
• patients with hemorrhagic tendencies
• blood dyscrasias
• malignant hypertension
• has a number of clinically significant drug interactions which should be assessed prior to initiation of therapy

Question 6

warfarin (1)

Answer 6

vitamin K antagonist

• Coumadin* (brand name D/C)

Question 7

Dosage Forms and Strengths

Generic Warfarin (1)

Answer 7

tabs: 1, 2, 2.5, 3, 4, 5, 6, 7.5, 10 mg

Question 8

heparin (1)

Answer 8

unfractionated heparin

• Heparin LEO**

Question 9

Dosage Forms and Strengths

Heparin LEO (2)

Answer 9

• IV injection soln: 100 IU/mL (generic not available)
• IV/SC injection soln: 1000 IU/mL (generic not available)

Question 10

Dosage Forms and Strengths

Generic Heparin (1)

Answer 10

IV/SC injection soln: 1000, 10000 IU/mL

Question 11

enoxaparin (2)

Answer 11

low molecular weight heparin

• Lovenox
• Lovenox HP

Question 12

Dosage Forms and Strengths

Lovenox (1)

Answer 12

pre-filled syringes (SC/IV): 30 mg/0.3 mL, 40 mg/0.4 mL, 60 mg/0.6 mL, 80 mg/0.8 mL, 100 mg/mL

Question 13

Dosage Forms and Strengths

Lovenox HP (1)

Answer 13

pre-filled syringes (SC/IV): 120 mg/0.8 mL, 150 mg/mL

(150 mg/mL)

Question 14

dalteparin (1)

Answer 14

low molecular weight heparin

• Fragmin

Question 15

Dosage Forms and Strengths

Fragmin (1)

Answer 15

pre-filled syringes (SC/IV): 2500 IU/0.2 mL, 3500 IU/0.28 mL, 5000 IU/0.2 mL, 7500 IU/0.3 mL, 10,000 IU/0.4 mL, 12,500 IU/0.5 mL, 15,000 IU/0.6 mL, 16,500 IU/0.66 mL, 18,000 IU/0.72 mL, 25,000 IU/1 mL

Question 16

rivaroxaban (1)

Answer 16

direct factor Xa inhibitor

• Xarelto*

Question 17

Dosage Forms and Strengths

Xarelto (2)

Answer 17

• tabs: 2.5, 10, 15, 20 mg
• granules: 1 mg/mL (when reconstituted)

Question 18

apixaban (1)

Answer 18

direct factor Xa inhibitor

• Eliquis*

Question 19

Dosage Forms and Strengths

Eliquis (1)

Answer 19

tabs: 2.5, 5 mg

Question 20

edoxaban (1)

Answer 20

direct factor Xa inhibitor

• Lixiana

Question 21

Dosage Forms and Strengths

Lixiana (1)

Answer 21

tabs: 15, 30, 60 mg

Question 22

fondaparinux (1)

Answer 22

indirect factor Xa inhibitor

• Arixtra*

Question 23

Dosage Forms and Strengths

Arixtra (1)

Answer 23

injection soln: 2.5 mg/0.5 mL, 7.5 mg/0.6 mL

Question 24

dabigatran (1)

Answer 24

direct thrombin inhibitor

• Pradaxa*

Question 25

Dosage Forms and Strengths Pradaxa (1)

Answer 25

caps: 75, 110, 150 mg