Anticonvulsants Flashcards Preview

Exam 8 > Anticonvulsants > Flashcards

Flashcards in Anticonvulsants Deck (41):
1

Initial DOC in all seizures (except for absence and atonic)

Phenytoin

2

Intramuscular injection results in crystallization and muscle necrosis

Phenytoin

3

Metabolism rate limited and enzyme becomes saturable. Zero order kinetics

Phenytoin

4

Most common drug to cause gingivial hyperplasia and hirsuitism (may affect teenage girl's compliance)

Phenytoin

5

Nystagmus

Phenytoin

6

Stevens Johnsons and hematological rxs warrant cessation of treatment

phenytoin

7

Fetal abnormalities - cleft lip and palate

Phenytoin

8

Induces CYP3A4

Phenytoin

9

May cause cardiovascular collapse if given IV

Phenytoin

10

Inhibits seizure spread. Blocks Ca influx and enhances Cl mediated inhibitory post synaptic potentials

Phenytoin

11

Fosphenytoin

Prodrug of phenytoin

12

Used for trigeminal neuralgia

carbamazepine

13

Don't give for myoclonic seizures because it may worsen them

carbamazepine

14

Autoinduces own metabolism and causes hepatotoxicity

Carbamazepine

15

Enhances GABA. Additive with other CNS depressants (can easily die from respiratory depression)

Phenobarbitol

16

Used in pts with epilepsy stabilized on this drug 25 yrs ago

Phenobarbitol

17

Primidone, ethotoin, and felbamate

anticonvulsants

18

Enhances GABA and blocks Na channel > wide range of effects

valproic acid

19

Used in absence seizures

valproic acid and ethosuximide

20

Multiple formulations (can be sprinkled on kid's food). Potential birth defects

valproic acid

21

Alopecia

Valproic acid

22

Possible decrease in platelets and clotting functions (avoid in bleeding disorders)

Valproic Acid

23

Induces P450s

Valproic acid

24

Agonists at GABA-a receptors

benzos

25

clonazepam and diazepam used for

status epilepticus

26

Used for diabetic neuropathy

Gabapentin

27

Weight gain, constipation

gabapentin

28

potentiates opioid actions. Co-abuse with opioids because it gives better high

gabapentin

29

Inhibits v-gated Na channels, Ca channels, and glutamate release

lamotrigine

30

Can induce own metabolism

lamotrigine

31

drug with HIGHEST potential for stephens johnson

lamotrigine

32

Decreased cognitive ability (makes ppl dopey)

Topiramate

33

Renal stone formation (avoid if hx of kidney stones)

Topiramate

34

Tiagabine

anticonvulsant

35

Unknown MOA. Safe and becoming more popular

Levetiracetam

36

Hyponatremia

Oxcarbazepine

37

Neuropathic pain and diabetic peripheral neuropathy

Pregabalin

38

Block Na channels and t-type Ca channels

Zonisamide

39

Used for status epilepticus

Phenobarbitols

40

Vigabatrin

is anticonvulsant

41

Highly protein bound in plasma

Phenytoin