Flashcards in Anticonvulsants Deck (54):
Uncontrolled physiologic responses due to a generalized pronounced abnormal discharge of electrical activity in nerve cells?
Seizures are mainly __________ but can be caused by:
-Alterations in body chem (hypoxia,acedosis)
The aim of drug treatment for seizures is to:
Prevent abnormal nerve activity.
Anticonvulsants prevent abnormal activity by:
Decreasing initial discharge of impulses
Preventing the spread of elec. discharge
Anticonvulsants work by:
-Inhibiting movements of electrolytes across cell membrane
Facilitating natural inhibitory elec. mech.
Altering synaptic transmissions
5 Types of Anticonvulsants (HBSBM)
These are the most frequently prescribed of the anticonvulsants.
This drug is the representative of hydantoins:
T/F IM should be avoided for phenytoin.
TRUE - Drug precipitates in tissue and is absorbed erratically.
300-600 divided by 3 doses per day
4-8mg per kg of body weight, divvied in 2-3
In patients with impaired liver funxn, phenytoin doses should be...
T/F Phenytoin causes strong CNS depression.
Most common side fx of phenytoin are:
CNS Depression, sluggishness, blurred speech, ataxia
Phenytoin is often not used in children because it causes..
Hyperplasia of gums (Overgrown)
Phenytoin might be popular with bears because it causes..
Phenytoin can also cause (fever, sore throat)
Phenytoin also decreases the absorption of folic acid which can lead to..
To avoid GI problems, take phenytoin..
It is believed that these raise the neuronal firing threshold:
Two types of barbituates only are used to prevent seizures:
T/F Barbituates are under the Narc. Control Act.
T/F Phenobarbital is the first choice for kids.
Phenobarbital is also useful in treating ________ _______ & ___________ in children.
Phenobarbital is available in two preps.
PO & IM
T/F Tolerance can develop to phenobarbital.
TRUE - increase dose over time
Dose range for adults?
100-300 single or divided
Children & barbs?
3-5 per kg divvi by 1 or 2
As barbituates are good CNS depressants, we assess for:
Sedation & Drowsiness
While they may be good for kids, they can also cause:
Abrupt withdrawal from barbs can induce:
Beware other _______ when taking barbs.
This other seizure drug inhibits the metabolism of phenobarb.
Phenobarbital also stimulates liver enzymes causing:
Increase in metabolism of all other drugs!
These drugs are chemically unrelated to hydantoins and barbiturates.
Most commonly used succinimide?
The perk of ethosuximide is that it treats these types of seizures which all others don't.
Petit Mal (Absence) Seizures
1500 in 2 doses
1000mg or 20mg per kg in 2 doses
Ethosuximide can unfortunately cause serious allergic reactions &...
Anemia & Agranulocytosis
These benzos are good for seizures.
Miscellaneous drugs used to treat seizures include:
Carbamazepine is useful in treating
All seizures (no petit mal) and MANIA!!
Carbamazepine can cause serious blood..
Dyscrasias! Abnormailty in strux,funx,population
Valproc Acid is useful for..
All seizures & Bipolar!
The action of Valproic Acid occurs at
The unique formation of valproic acid with less GI effects is called:
Side fx of VA are primarily
GI - N/V/indigestion
Glargines best friend?
Lamotrigine is one of the _____ anticonvulsants.
Lamotrigine is a sister to (menalgia)
Lamotrigine is useful for:
All seizures & mania
Lamotrigine is evil & with this patch man from days can cause death:
Steven-Johnsons Syndrome!! Severe rash