Antidepressants

Question 1

MAOIs?

Answer 1

Tranylcypromine, Phenelzine

Question 2

Tranylcypromine class?

Answer 2

MAOI

Question 3

Phenelzine class?

Answer 3

MAOI

Question 4

MAOI mxn?

Answer 4

Irr inhibit MAOa,b

Question 5

MAOI for?

Answer 5

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

Question 6

MAOI side effects?

Answer 6

HTN crisis (w/ tyramine-rich foods), Seretonin syndrome (MAOI + SSRI), agitation (rare), delerium & seizures, anticholinergic, orthostatic HTN, sexual dysfunction, weight gain, sedation

Question 7

Tricyclics?

Answer 7

Desipramine, Imipramine, Amitryptyline, Nortriptyline

Question 8

Desipramine class?

Answer 8

Tricyclic

Question 9

Imipramine class?

Answer 9

Tricyclic

Question 10

Amitrytptiline class?

Answer 10

Tricyclic

Question 11

Tricyclic mxn?

Answer 11

Block NE, 5HT reuptake (at varying potencies & selectivity); variably block muscarinic, alpha adren, DA, hist receptors

Question 12

Tricyclics for?

Answer 12

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, (Amitrytpyline: prevention of tension headaches, migraines)

Question 13

Tricyclic side effects?

Answer 13

Sympathomimetic (cardiac arrythmias and conduction defects, especially at OD), antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures

Question 14

What active metabolite does imipramine form? What about amitryptyline?

Answer 14

Desipramine; Nortriptyline.

Question 15

Are the TCAs safe?

Answer 15

Not really…rarely used anymore.

Question 16

Nortriptyline class?

Answer 16

Tricyclic

Question 17

SSRIs?

Answer 17

Fluoxetine, Paroxetine, Sertraline, Escitalopram, Citalopram

Question 18

Fluoxetine class?

Answer 18

SSRI

Question 19

Paroxetine class?

Answer 19

SSRI

Question 20

Sertraline class?

Answer 20

SSRI

Question 21

Escitalopram class?

Answer 21

SSRI

Question 22

Citalopram class?

Answer 22

SSRI

Question 23

SSRI mxn?

Answer 23

Inhibit reuptake of 5HT (& NE to a lesser extent)

Question 24

SSRI for?

Answer 24

depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

Question 25

Which SSRIs is a potent P450 inhibitor?

Answer 25

Fluoxetine & Paroxetine. Fluoxetine forms norfluoxetine as an active metabolite

Question 26

SNRIs?

Answer 26

Duloxetine, Venlafaxine

Question 27

Duloxetine class?

Answer 27

SNRI

Question 28

Venlafaxine class?

Answer 28

SNRI

Question 29

SNRI mxn?

Answer 29

Inhibit reuptake of NE & 5HT

Question 30

SNRI for?

Answer 30

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

Question 31

Atypical antidepressants?

Answer 31

Bupropion, Mirtazapine

Question 32

Bupropion mxn?

Answer 32

Atypical: Blocks DA & NE reuptake

Question 33

Bupropion for?

Answer 33

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism, nicotine abstinence

Question 34

Bupropion side effect?

Answer 34

Lowers seizure threshold

Question 35

Mirtazapine mxn?

Answer 35

Atypical: 5HT2a antagonist; Inhibit 5HT reuptake

Question 36

Mirtazapine for?

Answer 36

Depression, anziety, PTSD, chronic pain, enuresis, bulimia, alcoholism

Question 37

Lithium mxn?

Answer 37

??? -- Depletes secondary messengers IP3 and DAG (which are important in alpha adrenergic and muscarinic cholinergic transmission)

Question 38

Lithium for?

Answer 38

Anti-manic/mood-stabilizing (bipolar); Long term cluster headache prevention

Question 39

Lithium side effects?

Answer 39

If elevated levels; neurotoxicity, cardiac toxicity, renal dysfunction. Drowsiness, weight gain, tremor, polydisplia, polyuria, avoid indomethacin and Na-depleting diuretics...Nausea & vomiting are early signs of lithium OD

Question 40

Besides lithium, what is also helpful in treating bipolar?

Answer 40

Anti-epileptics: Carbamazepine, Valproate, MAOIs (during depressive phases), concurrent use of benzodiazepines (b/c Li onset is slow), antipsychotics (when severe)

Question 41

SSRI side effects?

Answer 41

Serotionin syndrome, nausea, sexual dysfunction -- fewer than TCAs