Antidepressants: TCAs Flashcards Preview

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Flashcards in Antidepressants: TCAs Deck (18):
1

What does TCA stand for?

Tricyclic antidepressants

2

What are the most common adverse effects of TCAs? (3)

Sedation
Orthostatic hypotension
Anticholinergic effects

3

What is the most dangerous effect of TCAs?

Cardiac toxicity

4

What is the mechanism of action of TCAs?

Block reuptake of serotonin and norepinephrine

5

What type of neurotransmitters are serotonin and norepinephrine?

Monamines

6

What are 4 examples of TCAs?

Amitriptyline
Clomipramine
Imipramine
Nortriptyline

7

TCAs block neuronal reuptake of NE (norepinephrine) and 5-HT(serotonin). As a result, TCAs increase the concentration of these transmitters at CNS synapses, and thereby _____ their effects.

Intensifies

8

Do all TCAs block the reuptake of NE AND 5-HT? Explain.

No; some TCAs block the reuptake of both NE and 5-HT, but others ONLY block the reuptake of NE!

9

If you take a TCA, will there be immediate therapeutic effects?

No, like SSRIs the biochemical effect (blocking of the transmitter reuptake) will occur within hours...BUT therapeutic effects develop over WEEKS

10

True or False: TCAs are often used beyond depression.
Explain

True; they are also used for treatment in bipolar disorder, fibromyalgia syndrome, and other uses

11

What are the most common adverse effects of TCAs?

Orthostatic hypotension
Anticholinergic effects
Sedation

12

What is the most serious of the common adverse responses to TCAs?

Orthostatic hypotension

13

TCAs can block muscarinic cholinergic receptors, which causes what kind of effects?
*Remember cholinergic is associated with acetylcholine*

What else can TCA block besides acetycholine?

Cant see
Cant pee
Cant spit
Cant shit

Histamine

14

TCAs: Too much receptor activation causes ______.
(from the notes)

Seizures

15

Can we combine TCAs with MAOIs? Why or why not?

No. That combination can lead to severe hypertension

16

Do TCAs cause CNS sedation or elevation?

Sedation

17

How should all TCAs be administered? Any exceptions?

By mouth; yes only one (imipramine), which can be given IM

18

Are TCAs dirty drugs or clean drugs?

Dirty