Flashcards in Antidepressants: TCAs Deck (18):
What does TCA stand for?
What are the most common adverse effects of TCAs? (3)
What is the most dangerous effect of TCAs?
What is the mechanism of action of TCAs?
Block reuptake of serotonin and norepinephrine
What type of neurotransmitters are serotonin and norepinephrine?
What are 4 examples of TCAs?
TCAs block neuronal reuptake of NE (norepinephrine) and 5-HT(serotonin). As a result, TCAs increase the concentration of these transmitters at CNS synapses, and thereby _____ their effects.
Do all TCAs block the reuptake of NE AND 5-HT? Explain.
No; some TCAs block the reuptake of both NE and 5-HT, but others ONLY block the reuptake of NE!
If you take a TCA, will there be immediate therapeutic effects?
No, like SSRIs the biochemical effect (blocking of the transmitter reuptake) will occur within hours...BUT therapeutic effects develop over WEEKS
True or False: TCAs are often used beyond depression.
True; they are also used for treatment in bipolar disorder, fibromyalgia syndrome, and other uses
What are the most common adverse effects of TCAs?
What is the most serious of the common adverse responses to TCAs?
TCAs can block muscarinic cholinergic receptors, which causes what kind of effects?
*Remember cholinergic is associated with acetylcholine*
What else can TCA block besides acetycholine?
TCAs: Too much receptor activation causes ______.
(from the notes)
Can we combine TCAs with MAOIs? Why or why not?
No. That combination can lead to severe hypertension
Do TCAs cause CNS sedation or elevation?
How should all TCAs be administered? Any exceptions?
By mouth; yes only one (imipramine), which can be given IM