Antidysrhythmic Drugs Flashcards

1
Q

How do we treat arrhythmias

A

Abnormal impulse generation
abnormal calculation

treatment: suppress abnormal impulses
inhibit abnormal conduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

vaughan williams classification

A

system that is commonly used to classify antidysrhythmic drugs
based on the electrophysiologuc effect of particular drugs on the action potentia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

class 1 mechanism

A

membrane-stabilizing drugs

fast sodium channel blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

class 1 a action and indications

A

quinidine(long term)
procainamide(short term)
disopyramide

block sodium channels
delay repolarization
increases action potential duration
used for atrial fibrillation, premature atrial contractions, premature ventricular contractions, ventricular tachycardia, wolff-parkinson-white syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

class 1a adverse drug reactions

A
QT prolongation leading to Torsades de points
Intracardiac vagal block
GI disturbances
Cinchonism
SLE and agranulocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Class1b: action and indication

A
  • phenytoin, lidocaine
  • block sodium channels
  • accelerate repolarization
  • increase or decrease action potential duration
  • used for ventricular dysrhythmias only
  • premature ventricular contractions, ventricular tachycardia, ventricular fibrillation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Class 1b Adverse Effects

A
drowsiness
Slurred speech
parasthesias
agitation
confusion
convulsions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

class 1c action and indications

A

flecainide, propafenone

  • block sodium channels
  • little effect on repolarization
  • used for severe ventricular dysrhythmias may be used in atrial fibrillation/flutter, wolff-parkinson-white syndrome, supraventricular tachycardia dysrhythmias
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Class 1c adverse effects

A
  • negative ionotropic effect, thus can aggravate HF
  • dizziness
  • blurred vision
  • headache
  • nause
  • aggravate preexisting arrhythmias
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Class 2 beta blockers action and indications

A

atenolol, esmolol, metaprolol, propranolol

  • reduce or block sympathetic nervous system stimulation, thus reducing transmission of impulses in the hearts conduction system
  • depress phase 4 depolarization
  • general myocardial depressants for both supraventricular and ventricular dysrhythmias
  • also used as antianginal and antihypertensive drugs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

class 2 beta blockers adverse effects

A

hypotension
impaired lipid metabolism
bronchospasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

class 3: action and indications

A

amiodarone, sotalol, ibulitide
potassium channel blockers
increase APD
prolong repolarization in phase 3
used for dysrhythmias that are difficult to treat
-life-threatening ventricular tachycardias or fibrillation, atrial fibrillaion or flutter-resistnt to other drugs
-sustained ventricular tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

class 4 action and indications

A
verapamil, diltiazem
calcium channel blockers
-inhibit slow-channel pathways
Depress phase 4 depolarization
reduce AV node conduction
used for paroxysmal supraventricular tachycardia, rate control for atrial fibrillation and flutter
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

class 5

A

digoxin, adenosine

-have properties of several classes and are not placed into one particular class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

adenosine

A

-slows conduction through the AV node
-used to convert paroxysmal supraventricular tachycardia to sinus rhythm
-very short half life
only administered as fast IV push
may cause asystole for a few secons
other adverse effects are minimal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly