Antiemetics

Question 1

Droperidol Receptor

Answer 1

D2

Question 2

Brand name for Droperidol

Answer 2

Inapsine

Question 3

Droperidol dose

Answer 3

0.626 mg

Question 4

Droperidol: Onset and Duration

Answer 4

Onset: 1-5 mins
Duration: 2 - 3 hours

Question 5

Brand Name for Promethazine

Answer 5

Phenergan

Question 6

Promethazine Receptor

Answer 6

• Histamine (H1)
• Muscarinic
• Dopamine
• Medullary Vomiting Center

Question 7

Promethazine dose

Answer 7

6.25 - 25 mg

Question 8

Promethazine Onset and Duration

Answer 8

Onset: 1-5 minutes
Duration: 4-6 hours

Question 9

Brand name of Ondansetron

Answer 9

Zofran

Question 10

Ondansetron Receptor

Answer 10

5-HT3

Question 11

Ondansetron dose

Answer 11

4 mg

Question 12

Ondansetron Onset and Duration

Answer 12

Onset: 10 mintes
Duration: 4-9 hours

Question 13

Brand name for Dexmethasone

Answer 13

Decadron

Question 14

Dexmethasone Receptor

Answer 14

Glucocorticoid Receptor (GR)

Question 15

Dexmethasone Dose

Answer 15

4 mg

Question 16

Dexmethasone onset and duration

Answer 16

Onset: 10 - 30 minutes
Duration: 2- 10 minutes

Question 17

Brand name for Metoclopramide

Answer 17

Reglan

Question 18

Metoclopramide Receptor

Answer 18

• D2
• 5-HT3

Question 19

Metoclopramide Dose

Answer 19

10 - 20 mg

Question 20

Metoclopramide Onset and Duration

Answer 20

Onset: 10 mins
Duration: 2 hours

Question 21

Scopalamine Receptor

Answer 21

Muscarinic Antagonist

Question 22

Scopalamine dose

Answer 22

Patch (0.3 - 0.65 mg)

Question 23

Scopalamine Onset and Duration

Answer 23

Onset: 2-4 hours
Duration: 72 hours

Question 24

Propofol Anti-emtic Receptor

Answer 24

• GABA (stimultes)
• 5-HT3 (reduces)

Question 25

Propofol Anti-emetic dose

Answer 25

* 10 - 15 mg IV * Followed by 10 mcg/kg/min infussion

Question 26

PONV Risk Factors

Answer 26

* Female * Age > 40 * Hx PONV or Motion Sickness * Vertigo

Question 27

Surgical PONV Risk Factors

Answer 27

* Laparoscopy * Major Breast * Strabismus * Intraocular * Middle Ear * Tonsils * Adenoids * Neuro (Intracranial) * Gynecologic * Testicular * Scrotum * Kidney Stones

Question 28

# PONV Treatment Algorithm Patient has 0 risk factors. What is the % chance of PONV and Treatment?

Answer 28

* 10 % * Non-Pharmacological

Question 29

# PONV Treatment Algorithm Patient has 1 risk factors. What is the % chance of PONV and Treatment?

Answer 29

* 20% * 1 drug

Question 30

# PONV Treatment Algorithm Patient has 2 risk factors. What is the % chance of PONV and Treatment?

Answer 30

* 40% * 2 drugs

Question 31

# PONV Treatment Algorithm Patient has 3 risk factors. What is the % chance of PONV and Treatment?

Answer 31

* >60% * 3+ drugs