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Flashcards in Antiemetics Deck (17)
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1

What are the 2 classes of anti-emetics?

H1 antagonists
D2 Antagonists

2

What is the MOA of Promethiazine?

Non-selective central and peripheral H1 antagonist
Some D2 antagonism

3

What are the serious side effects of Promethiazine?

Thrombocytopenia
Agranulocytosis

4

What is the black box for Promethiazine?

Respiratory depression
Gangrene

5

What happens when Promethiazine interacts with Macrolides, Azoles, or CAIs?

Prolonged QT segment

6

Promethiazine may impair the metabolism of which drug?

Beta-blockers

7

Which drugs interact with Promethiazine to cause an additive effect?

Anticholinergics
Sedating antihistamines
Olopatadine

8

There is a seizure warning when Promethiazine interacts with which substance?

Omega-6

9

What is the MOA of Chlorpromazine?

D2 antagonism

10

What are the common side effects of Chlorpromazine?

Blurred vision
Ocular pigmentation
Photosensitivity

11

What is the serious side effect of Chlorpromazine?

Blood dyscrasias

12

There is a seizure risk when Chlorpromazine interacts with what?

Omega-6

13

What type of drug is Ondansteron?

5-HT3 Antagonist

14

What is the indication for Ondansteron?

Chemo/e-ray nausea and vomiting

15

What are the serious adverse effects of Ondansteron?

SJS
TEN
Serotonin syndrome

16

What are the ocular side effects of Ondansteron?

Transient blindness
Oculogyric crisis

17

Which drugs may interact with Ondansteron to cause a prolonged QT segment?

Macrolides
Azoles
CAIs