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Pharma 3 > Antiepileptic > Flashcards

Antiepileptic Flashcards

(52 cards)

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1
Q

Status seizures or status epilepticus

A

Continuous or repeated epileptic seizures for atleast 30 minutes without regaining consciousness in between

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2
Q

Different form of epilepsy

A

Focal, generalized, combined,forms of unknown origin

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3
Q

Generalized epilepsy two form

A

Grand mal(tonic clinic), petite mal Absence

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4
Q

Tonic seizures

A

Increase muscle tone

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5
Q

Clonic seizures

A

Increase muscle twitching

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6
Q

Vegetative seizures

A

Has peculiar epigastric sensation

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7
Q

Sodium channel blockers in antiepileptic

A

Carbamazepine, valproic acid , Lamotrigine, Topiramate

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8
Q

T type calcium channel blockers in antiepileptic

A

Ethosuximide and valproic acid

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9
Q

High voltage calcium channel blockers in antiepileptic

A

Gabapentin, Lamotrigine, Topiramate

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10
Q

GABA a receptor allosteric modulator

A

Phenobarbital and Topiramate

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11
Q

GABA transaminase inhibitor

A

Valproic acid

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12
Q

SV2A action in antiepileptic drigs

A

Levetiracetam

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13
Q

Ampa /kainate receptor antagonist

A

Topiramate

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14
Q

Focal epilepsy can be treated by

A

Phenobarbital, Gabapentin,, Carbamazepine, valproic acid, Lamotrigine, Topiramate and levetiracetam

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15
Q

Tonic clinic form is treatment

A

Phenobarbital, carbamazepine, valproic acid, Lamotrigine, Topiramate and levetiracetam

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16
Q

Absence epilepsy treatment

A

Ethosuximide and valproic acid, Lamotrigine

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17
Q

Status epilepticus treatment

A

Phenobarbital, valproic acid, levetiracetam

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18
Q

Ethosuximide is a

A

T type (low voltage calcium channel blocker , work only on absence seizures

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19
Q

Phenobarbital is a

A

GABA allosteric modulator,treats ,focal ,tonic clinic and status epilepticus

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20
Q

Gabapentin is a

A

High voltage calcium channel blockers,works only on Focal epilepsy

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21
Q

Carbamazepine is a

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A

Sodium channel blocker,works only on Focal and tonic clinic epilepsy

22
Q

Lamotrigine is a

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A

Sodium channel blocker and high voltage calcium channel blockers ,treats focal, tonic clonic and absence epilepsy

23
Q

Levetiracetam is a

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A

SV2A antagonist,focal, tonic clonic and status epilepticus

24
Q

Topiramate is a

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A

Sodium channel blocker and high v calcium channel blockers,GABA A allosteric modulator,AMPA receptor antagonist -focal epilepsy,Tonic clonic E

25
Valproic acid
Na channel blocker,LV calcium channel blockers,GABA transaminase inhibitor,, treatment of all type of epilepsy
26
Levetiracetam and phenobarbital can be used in treatment of
Focal, tonic clonic and status epilepticus
27
Lamotrigine treat
Focal , Tonic clonic and absence
28
Nti seizures drugs acting on status epilepticus
Diazepam, midazolam, valproic acid, phenobarbital, lorazepam levetiracetam
29
SE valproic acid
Teratogenic effect
30
Carbamazepine use
Bipolar disorders, neuropathic pain(trigeminal neuralgia), general TC and focal epilepsy
31
Gabapentin use
Focal epilepsy, neuropathic pain(diabetic neuropathy and post herpetic neuralgia), chronic pain syndrome
32
COMT inhibitor
Entacapone and tolcapone
33
Central acting cholinoreceptor blocker
Trihexyphenidyl
34
MAO inhibitor
Selegiline
35
NMDA receptor antagonist
Amntadine
36
Dopamine precursor or dopamine receptor agonists
Levodopa/benserazide,carbidopa,pramipexole
37
Parkinsons disease symptoms
Tremor, bradykinesia rigidity,postural instability
38
Carbidopa doesn't cross
BBB and inhibits peripheral metabolism ofL-dopa,so that more dopamine available in CNS
39
L dopa can be used as antiparkinsonian and al see o it reduces
EPS
40
Carbidopa and benserazide are
Levodopa metabolism inhibitors or decarboxylase inhibitors
41
Dopamine induced GIT SE
Nausea, vomiting
42
Dopamine induced cardiovascular SE
Arrythmia and hypotension
43
L dopa can cause
NMS
44
Wearing off means
Exacerbation of disease
45
On off phenomena
Acute cycles of exacerbation of symptoms throughout the day
46
Levodopa induced dyskinesia
Involuntary movement during on time and bradykinesia during off time
47
Levodopa use
Parkinson disease and Parkinsonism
48
Trihexyphenidyl use
EPs, parkinsonism
49
Antidementia agents
NMDA receptor antagonist -memantine Anticholineserases-donezepil,rivastigmine
50
SE of ACH esterase inhibitor
Cholinergic hyperactivation
51
Use of donezapil
Alzheimer's dementia, vascular dementia, Parkinson's dementia
52
NMDA receptor channel blocker memantine use
Alzheimer's dementia

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