Antifungal

Question 1

Azoles

Answer 1

Fluconazole, itraconazole

Inhibit fungal sterol (ergosterol) synthesis

Used for local and less serious systemic mycoses (cryptococcal meningitis, blastomyces, coccidiodies, histoplasma)

Cause testosterone synthesis inhibition, liver dysfunction (P-450 inhibition)

Question 2

Flucytosine

Answer 2

Inhibit DNA and RNA biosynthesis

Used for systemic fungal infection in combination with amphotericin B

Cause bone marrow suppression

Question 3

Echinocandins

Answer 3

Caspofungin, micafungin

Inhibit cell wall synthesis

Used for invasive aspergillosis, Candida

Cause GI upset, headaches, hepatotoxicity

Question 4

Griseofulvin

Answer 4

Interferes w/ microtubule function and disrupts mitosis

Oral treatment for superficial infections

Tertatogenic, carcinogenic

Question 5

Chloroquine

Answer 5

Blocks detoxification of heme into hemozoin leading to heme accumulation

Treatment of plasmodial species

Cause retinopathy, pruritus