antifungal Flashcards
(4 cards)
1
Q
How does candida azole resistance occur?
A
CaMdr1p major facilitator superfamily (MFS) anti-fungal efflux pump.
Alterations in the azole target protein - Erg11p
Upregulation of Erg11p gene
2
Q
What is the azole MOA?
A
Target site = Erg11p
Inhibition leads to inhibition of ergosterol biosynthesis and accumulation of toxic sterol intermediates
3
Q
Why is clinical resistance rare against azoles?
A
Fungi do utilise sterols other than ergosterol as a major component of their cell membrane - survival pressure does not build up.
4
Q
What is the MOA of Griseolfulvin?
A
Accumulates in the precursor keratin cells to prevent transmission of the fungi to unexfolidated skin cells. Interfers with tubulin.
