Antifungal Flashcards Preview

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Flashcards in Antifungal Deck (10):
1

Amphotericicn B

Mechanism: membrane function; binds ergosterol creates pores

Main Toxicity: fever, chills, Nephrotoxicity, anemia

2

Ketoconazole

Mechanism: 14 alpha demethylase inhibitor, p-450

Main Toxicity: endocrine abnormalities, GI N/V

3

Miconazole

Mechanism: 14 alpha- demethylase inhibitor, ergosterol synthesis inhibitor

Main Toxicity: low toxicity

4

Fluconazole

Mechanism: 14 alpha demethylase inhibitor, ergosterol biosynthesis inhibitor

Main Toxicity: low toxicity

5

Itraconazole

Mechanism: 14 alpha demethylase inhibitor, ergosterol biosynthesis inhibitor

Main Toxicity: low

6

Griseofulvim

Mechanism: bundles and binds microtubules, halting mitosis in metaphase, deposited in keratin precursor cells

Main Toxicity: CNS= HA, GI=N/V, HS= rare

7

Nystatin

Mechanism: binds to ergosterol membrane making pores

Main Toxicity: low

only P.O.

8

Tolnaftate

Mechanism: inhibits squalene monoxygenase,

Main Toxicity: low

9

Terbinafine HCl

Mechanism: inhibits squalene monoxygenase

Main Toxicity: low

10

Caspofungin

Mechanism: blocks synthesis of beta 1,3 D glucan, a polysacarhide of fungal cell wall

Main Toxicity: Fever, rash, vomiting

*Use: esophageal candidiasis