AntiFungals

Question 1

Name the AntiFungals

Answer 1

Polyenes: Amphotericin B, Nystatin
Echinoconadins “Fungins” - Caspofungin
Azoles - Fluconazole, Itraconazole, Voriconazole
Others- Griseofulvin, Terbinafine, Flucytosine

Question 2

Polyenes have lots of _____ that help them to make _____ in the ___ ______.

Answer 2

Double Bonds
Pores
Cell Membrane

Question 3

Amphotericin B

Answer 3

• Broadest of Antifungals
• Membrane Function Inhibitor
• Pore into membrane by binding with ergosterol
• IV admin (often with lipid for better solubility)
• Kidney excre
• Can bind human cholesterol so SLOW AND LOW to avoid renal damage
• Meningitis but only if directly administered to CSF
• USE IN PREGNANCY OVER AZOLES

Question 4

Membrane function inhibitor AntiFungals

Answer 4

Polyenes: Amphotericin B and Nystatin

Question 5

Nystatin

Answer 5

• Membrane Function Inhibitor
• TOPICAL ONLY
• Mostly Candida

Question 6

Caspofungin

Answer 6

• Cell Wall Synthesis Inhibitiion
• Blocks synthesis of b-glucans, which are cell wall building blocks
• Aspergillus and Candida ONLY
• IV only
• Kidney and liver excre.

Question 7

AntiFungals that inhibit Ergosterol Synthesis

Answer 7

• Azoles - Fluconazole, Itraconazole, Voriconazole

* Terbinafine

Question 8

Azoles

Answer 8

Flucon~
Itracon~
Voricon~
**ALL PREGNANCY CAT C

Question 9

Fluconazole

Answer 9

• Ergosterol synthesis inh, last steps of synth inhibited
• BROADER spectrum in azoles, including pseudallescherichia boydii resistant to AmphotericinB
• *NO ACTION AGAINST ASPERGILLUS or FILAMENTOUS FUNGI
• Good CNS
• INHIBITS p450!!
• Not for preg