Antifungals Flashcards Preview

SP18: Pharm Final > Antifungals > Flashcards

Flashcards in Antifungals Deck (15):
1

Which antifungal agent inhibits microtubules and is better absorbed with a fatty meal?

Griseofulvin

2

What is the mechanism of 5-FC?

Inhibits DNA, RNA synthesis

3

Due to high resistance, what drugs is 5-FC often combined with?

Amphotericin B, and newer azoles

4

What is the mechanism of Ampho B?

Binds to the membrane and creates pores for other drugs to get in

5

T/F: Ampho B can cause serious toxicity in patients with poor kidney function.

True

6

Compare Flucytosine (5-FC) and Amphotericin B.

5-FC - good PK (orally absorbed, soluble) but narrow spectrum and resistance

Ampho B - poor PK, but wide spectrum

7

Which drug is used to treat serious life threatening fungal infections?

Ampho B

IV only

8

T/F: Azole antigungals will end in -azole.

True

9

What is an important consideration with using azoles?

It binds heme of lanosterol in fungi but will cause drug-drug interactions due to inhibition of liver P450 enzymes

10

Which drug would be good for treating Cryptococcal meningitis in an AIDS patient?

Fluconazole

pH independent

11

T/F: Many azoles are very pH dependent for absorption.

True

Do not take antacids

12

Which antifungal is best for aspirgillosis?

Itraconazole and posaconazole

13

What are two polyene antifungals that will inhibit ergosterol?

Ampho B and Nystatin

14

T/F: Azoles will inhibit lanosterol.

True

15

What are two allylamines that will inhibit squalene epoxidase?

Terbinafine and Naftifine