Flashcards in Antifungals Deck (15):
Which antifungal agent inhibits microtubules and is better absorbed with a fatty meal?
What is the mechanism of 5-FC?
Inhibits DNA, RNA synthesis
Due to high resistance, what drugs is 5-FC often combined with?
Amphotericin B, and newer azoles
What is the mechanism of Ampho B?
Binds to the membrane and creates pores for other drugs to get in
T/F: Ampho B can cause serious toxicity in patients with poor kidney function.
Compare Flucytosine (5-FC) and Amphotericin B.
5-FC - good PK (orally absorbed, soluble) but narrow spectrum and resistance
Ampho B - poor PK, but wide spectrum
Which drug is used to treat serious life threatening fungal infections?
T/F: Azole antigungals will end in -azole.
What is an important consideration with using azoles?
It binds heme of lanosterol in fungi but will cause drug-drug interactions due to inhibition of liver P450 enzymes
Which drug would be good for treating Cryptococcal meningitis in an AIDS patient?
T/F: Many azoles are very pH dependent for absorption.
Do not take antacids
Which antifungal is best for aspirgillosis?
Itraconazole and posaconazole
What are two polyene antifungals that will inhibit ergosterol?
Ampho B and Nystatin
T/F: Azoles will inhibit lanosterol.