Antifungals & antiprotozoans Flashcards Preview

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Flashcards in Antifungals & antiprotozoans Deck (14):
1

Binds ergosterol --> lyses membrane.
Supplement K+ and Mg+ d/t alt. renal perm.

SE: fever/chills (shake and bake), hypotension, nephrotoxicity, arrhythmias, anemia, IV phlebitis

Amphotericin B

2

Binds ergosterol --> lyses membrane. Topical only. "Swish and swallow" for thrush

Nystatin

3

Inhibit ergosterol synthesis by inhibiting the fungal P450 that converts lanosterol to ergosterol.
SE: gynecomastia, inhibits P450

Azoles

4

Inhibits DNA and RNA biosynthesis by conversion to 5-FU by cytosine deaminase.
CU: Cryptococcal meningitis w/ Ampho B
SE: BMS

Flucytosine

5

Inhibits cell wall synthesis by inhibiting synthesis of beta-glucan.
CU: Invasive aspergillosis, Candida
SE: GI, flushing (histamine release)

Echocandins (caspofungin)

6

Inhibits squalene epoxidase.
CU: dermatophytes
SE: GI, hepatotoxic, taste disturbances

Terbinafine

7

Interferes with microtubule function. Disrupts mitosis. Deposits in keratin-containing tissues (e.g. nails).
CU: dermatophytes
SE: teratogenic, P450 inducer

Griseofulvin

8

Tx: toxo

Sulfadiazene + pyrimethamine

9

Tx: Trypanosoma brucei (African sleeping sickness)

Suramin and melarsoprol

10

Tx: Tryanosoma cruzi (Chaga's disease)

Nifurtimox

11

Tx: Leishmaniasis

Sodium stibogluconate

12

Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia.
SE: retinopathy, pruritis

Chloroquine

13

Tx: helminths

usually mebendazole

14

Tx: flukes (i.e. Schisto)

Praziquantel