Antiinflammatory Drugs chapter 25, 26' 35' 36 and 39 Flashcards Preview

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Flashcards in Antiinflammatory Drugs chapter 25, 26' 35' 36 and 39 Deck (22):
0

Contraindications of Tylenol

Liver dx
Viral hepatitis
Alcoholism
Renal impairment

1

Well absorbed from GI tract
Metabolized in liver, excreted by kidneys
Toxic to the liver
Inhibits prostaglandin synthesis (weak)
Inhibits hypothalamic heat regulating center
Well tolerated
Use with caution in patients with anemia

Tylenol

2

Tylenol overdose

No more than 4000 mg day

3

Anti inflammatory drugs pathophysiology

Inflammation - response to injury and infection

4

Cardinal signs of inflammation

Redness
Swelling
Heat
Pain
Loss of function

5

Chemical mediator of interest in anti inflammatory drugs

Prostaglandin

6

Antiinflammstory drug groups

NSAIDs
Corticosteroids

7

Aspirin action

Antiinflsmmstory, anti platelet, antipyretic effect

8

Aspirin pharmakinetics

Well absorbed from GI tract

9

Aspirin caution

Do not take with other NSAIDs (decreases effectiveness of other NSAID)
Avoid during third trimester
Do not give to children

10

Common side effect of aspirin

Gastric distress

11

Patient care plan

Assess for allergy/sensitivity, pain, inflammation and fever
Nursing diagnosis - alteration in comfort
Plan - administer med as directed with food

12

Para-chlorobenzoic acid

Indocin
Tolectin
Highly protein bound
Very irritating
May cause sodium and water retention and raise BP

13

Phenylactic-acid derivatives

Voltaren
No antipyretic effects
New topical form -lower risk of GI effects with equal efficacy

14

Toradol

First injectable

15

Propionic acid derivatives

Ibuprofens
Brand/trade name - Motrin, Advil, nuprin, medipren
Highly protein bound
Drug interactions - increase effects of warfarin, Sulfonamides, certain

16

Cox-2

Inflammation and pain
Drug agents Celebrex, relafen,
Contraindicated in patients with salicylate

17

NSAIDs in older adults

Assess GI status, renal function, and bp
Prescribed nsaid dose may need to be decreased

18

Steroids

Used frequently as an anti inflammatory agent
Not the drug of choice for arthritis due to many side effects

19

DMARDS

Immunosuppressive agents
Cancer suppressants Imuran, cytoxan, methotrexate
Immunomodulators
Interleukin receptor antagonists

20

Gout

The dx of kings
Disorder of uric acid and purine metabolism

21

Antiinflammstory gout drug

Colchacine and newest colcrys