Flashcards in Antimicrobial Chemotherapy Deck (23):
2 sites of action if antibiotics
- cell wall synthesis
- Nucleic acid synthesis
- Protein synthesis
Examples of antibiotics that inhibit cell wall synthesis
Penicillin and cephalosporins
Examples of antibiotics that inhibit protein synthesis
Gentamicin and erythromycin
Examples of antibiotics that inhibit nucleic acid synthesis
trimethoprim and ciprofloxacin
How do Beta lactams work
Disrupt peptidoglycan synthesis and inhibit PBP's
Examples of glycopeptides
Vancomycin and teicoplanin
When do glycopeptides act?
Stage earlier to beta lactams, inhibiting assembly of precursor
Do glycopeptides act only on gram positive or gram negative and why?
Gram positive as they cannot penetrate gram negative cell wall
Problem with Vancomycin?
Toxicity - otoxicity, nephrotoxicity and rashes
What are not sensitive to aminoglycosides
What are aminoglycosides usually used for
Serious gram negative (coliform) infections
Erythromycin and clarithromycin
What are macrolides used for
Gram positive infections for those allergic to penicillin's
Gram positives and MRSA
What do trimethroprim and sulphamethoxazole inhibit?
co - trimoxazole
Less likely to cause c diff
Ciprofloxacin inhibit DNA synthesis more directly
Gram negative - pseudomonas
Why can fluoroquinolones not be used in children?
Interfere with cartilage growth
Amoxicillin and clavulanic acid to combat beta lactamase resistance