Antimicrobial Chemotherapy Flashcards Preview

Principles of disease JK > Antimicrobial Chemotherapy > Flashcards

Flashcards in Antimicrobial Chemotherapy Deck (23)
Loading flashcards...
1
Q

2 sites of action if antibiotics

A
  • cell wall synthesis
  • Nucleic acid synthesis
  • Protein synthesis
2
Q

Examples of antibiotics that inhibit cell wall synthesis

A

Penicillin and cephalosporins

3
Q

Examples of antibiotics that inhibit protein synthesis

A

Gentamicin and erythromycin

4
Q

Examples of antibiotics that inhibit nucleic acid synthesis

A

trimethoprim and ciprofloxacin

5
Q

How do Beta lactams work

A

Disrupt peptidoglycan synthesis and inhibit PBP’s

6
Q

Examples of glycopeptides

A

Vancomycin and teicoplanin

7
Q

When do glycopeptides act?

A

Stage earlier to beta lactams, inhibiting assembly of precursor

8
Q

Do glycopeptides act only on gram positive or gram negative and why?

A

Gram positive as they cannot penetrate gram negative cell wall

9
Q

Problem with Vancomycin?

A

Toxicity - otoxicity, nephrotoxicity and rashes

10
Q

Aminoglycosides

A

Gentamicin

11
Q

What are not sensitive to aminoglycosides

A

Streptococci

12
Q

What are aminoglycosides usually used for

A

Serious gram negative (coliform) infections

13
Q

Macrolides

A

Erythromycin and clarithromycin

14
Q

What are macrolides used for

A

Gram positive infections for those allergic to penicillin’s

15
Q

Linezolid

A

Protein synthesis

MRSA

16
Q

Daptomycin

A

Gram positives and MRSA

17
Q

What do trimethroprim and sulphamethoxazole inhibit?

A

Purine synthesis

18
Q

co - trimoxazole

A

Less likely to cause c diff

19
Q

Trimethroprim

A

UTI

20
Q

Fluoroquinolones

A

Ciprofloxacin inhibit DNA synthesis more directly

Gram negative - pseudomonas

21
Q

Why can fluoroquinolones not be used in children?

A

Interfere with cartilage growth

22
Q

Co-amoxiclav

A

Amoxicillin and clavulanic acid to combat beta lactamase resistance

23
Q

What is flucloxacillin resistant to?

A

Beta lactamase and is antistaphylococcal