Antimicrobial Chemotherapy Flashcards Preview

Principles of disease JK > Antimicrobial Chemotherapy > Flashcards

Flashcards in Antimicrobial Chemotherapy Deck (23):
1

2 sites of action if antibiotics

- cell wall synthesis
- Nucleic acid synthesis
- Protein synthesis

2

Examples of antibiotics that inhibit cell wall synthesis

Penicillin and cephalosporins

3

Examples of antibiotics that inhibit protein synthesis

Gentamicin and erythromycin

4

Examples of antibiotics that inhibit nucleic acid synthesis

trimethoprim and ciprofloxacin

5

How do Beta lactams work

Disrupt peptidoglycan synthesis and inhibit PBP's

6

Examples of glycopeptides

Vancomycin and teicoplanin

7

When do glycopeptides act?

Stage earlier to beta lactams, inhibiting assembly of precursor

8

Do glycopeptides act only on gram positive or gram negative and why?

Gram positive as they cannot penetrate gram negative cell wall

9

Problem with Vancomycin?

Toxicity - otoxicity, nephrotoxicity and rashes

10

Aminoglycosides

Gentamicin

11

What are not sensitive to aminoglycosides

Streptococci

12

What are aminoglycosides usually used for

Serious gram negative (coliform) infections

13

Macrolides

Erythromycin and clarithromycin

14

What are macrolides used for

Gram positive infections for those allergic to penicillin's

15

Linezolid

Protein synthesis
MRSA

16

Daptomycin

Gram positives and MRSA

17

What do trimethroprim and sulphamethoxazole inhibit?

Purine synthesis

18

co - trimoxazole

Less likely to cause c diff

19

Trimethroprim

UTI

20

Fluoroquinolones

Ciprofloxacin inhibit DNA synthesis more directly
Gram negative - pseudomonas

21

Why can fluoroquinolones not be used in children?

Interfere with cartilage growth

22

Co-amoxiclav

Amoxicillin and clavulanic acid to combat beta lactamase resistance

23

What is flucloxacillin resistant to?

Beta lactamase and is antistaphylococcal