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NBDE Part II > Antimicrobials 1 H&D > Flashcards

Antimicrobials 1 H&D Flashcards

(52 cards)

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1
Q

Name the primary class of drugs that affect cell wall synthesis.

A

Beta lactams

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2
Q

What are the four subclasses of beta lactam antibiotics?

A

Penicillins (4 categories)Cephalosporins (5 generations)CarbapenemsMonobactams

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3
Q

To be effective, what four criteria must be met for beta lactams to be effective?

A
  1. evade bacterial defenses 2. penetrate outer cell layers to inner cytoplasmic membrane 3. keep the beta lactam ring intact 4. bind to transpeptidase
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4
Q

What is the ultimate method of action of beta-lactams?

A

They bind to active site of the PBP enzyme to prevent transpeptidation (terminal step in cell wall synthesis)

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5
Q

What is the only true naturally occurring penicillin?

A

Penicillin G

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6
Q

What two antimicrobials are natural penicillins?

A

Pen G, Pen V (aka Pen VK)

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7
Q

What are natural penicillins effective against?

A

sensitive strains of Gram + cocci (Pen G also active against some gram - Neisseria and anaerobes)

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8
Q

Are Natural penicillins narrow or broad spectrum?

A

Narrow spectrum

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9
Q

What are two Aminopenicillin antimicrobials?

A

Ampicillin, Amoxicillin

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10
Q

Since activity is extended compared to natural penicillins, aminopenicillins are referred to as what?

A

Extended spectrum penicillins(better Gram negative coverage than natural penicillins)

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11
Q

Aminopenicillins are administered with B-lactamase inhibitors such as? (3 names)

A

Clavulanate, Sulbactam, or Tazobactam

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12
Q

What is augmentin?

A

Amoxicillin + Clavulanate

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13
Q

Ampicillin should not be consumed with?

A

food, because the food binds to the drug and disables it

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14
Q

What are aminopenicillins effective against?

A

Sensitive Gram + and sensitive Gram - bacteria like H. flu, E. coli, Salmonella, Shigella

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15
Q

What is the drug of choice for standard prophylaxis for infective endocarditis?

A

Amoxicillin(if allergic, can take cephalexin, or non-B-lactams)

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16
Q

What three things interact with Ampicillin activity?

A

Hydrocortison (inactivates ampicillin), Oral contraceptives (inactivates contraceptive), and Probenecid (slows clearance of ampicillin)

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17
Q

What four antimicrobials are Penicillinase-resistant Penicillins (PRPs)?

A

methicillin, nafcillin, oxacillin, and dicloxacillin

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18
Q

PRPs are effective against what?

A

staphylococci, streptococci(NOT enterococci, anaerobic bacteria, gram - cocci or rods)

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19
Q

What two PRPs are normally acid stable (given PO) with a reduced risk of interstitial nephritis?

A

Oxacillin, Dicloxacillin(also undergo biliary excretion, not renal)

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20
Q

What is the drug of choice for serious Staphylococcus aureus infections that are non-methicillin resistant (non-MRSA)?

A

Nafcillin(Naf for Staph)

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21
Q

What does probenecid do that causes it to increase drug half-life and prolong clearance?

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A

Probenecid inhibits organic anion transporters in the proximal tubule, causing the drug to remain in the blood.

22
Q

What three drugs aren’t effected by probenecid?

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A

Nafcillin, oxacillin, dicloxacillin (¾ of penicillinase-resistant penicillins)

23
Q

Carboxypenicillins, ureidopenicillins, and monobactams are what kind of B-lactam?

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A

Anti-pseudonomal penicillins

24
Q

How are anti-pseudonomal penicillins administered?

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A

either intramuscular (IM) or intravenously (IV)NOT perorally (PO)

25
What kind of anti-pseudonomal penicillin are Indanyl carbenicillin and Ticarcillin?
Carboxypenicillins
26
What must be administered with ticarcillin?
Clavulanate (two are put into one dose in America - drug called Timentin)
27
What are anti-pseudonomal penicillins effective against?
Everything Pen G is effective against, plus Gram negative bacteria like Pseudonomas aerugenosa
28
What is Piperacillin?
An Ureidopenicillin (also broadest spectrum Penicillin)
29
Aztreonam is what?
A monobactam (an A-PP)(and great for pts with IgE-mediated penicillin allergy)
30
Anaphylactic reactions are more common when penicillin is administered __________?
Parenterally (other route than mouth/GI)
31
Name three allergic reactions to penicillin/B-lactams.
Anaphylactic (immediate - IgE mediated), Accelerated onset (30' - 48" after admin), Delayed onset (2+ days - 80-90% of rxs)
32
What are some signs/symptoms of anaphylaxis?
headache; lightheadedness; swelling of tongue, nose and/or throat; low BP; flushed skin; SOB; stridor; swelling of conjunctiva; etc
33
Large doses of Pen G may produce _____, confusion, twitching, ________, kidney failure, and _____.
lethargy, seizures, coma
34
10% of people are allergic to what?
Penicillins, and probably cross sensitive to all other B-lactams, including cephalosporins
35
What difference is there between the 5 generations of cephalosporins?
From gen 1 to 5, they increase in spectrum size and B-lactamase resistance. Moderate to broad.
36
All cephalosporins are bacteri____.
bactericidal
37
Which generation cephalosporin is active against MRSA?
Gen 5 (ceftaroline)
38
Cefazolin is which gen cephalosporin?
1 (don't penetrate CNS)
39
Cefaclor, Cefoxitin, Cefuroxime are which gen cephalosporin?
2 (good activity against E. coli, H. flu, and Klebsiella)
40
Cefoxitin is a ______ and is effective against mixed ________ infections, like peritonitis and pelvic inflammatory disease.
cephamycin, anaerobe
41
What cephalosporin crosses the blood brain barrier?
Cefuroxime
42
Cefotaxime, Ceftazidime, and Cefdinir are which gen cephalosporin?
3 (all of these penetrate CNS to treat meningitis)
43
Which cephalosporin is the highest selling and used to treat strep throat?
Cefdinir
44
Cefepime is which gen cephalosporin?
4 (good against Enterobacter, but poor against anaerobes)
45
Ceftaroline is which gen cephalosporin?
5
46
Ceftaroline is most commonly used to treat what three things?
MRSA, Pseudomonas and community-acquired pneumonia
47
What antimicrobial has the broadest spectrum known to man?
Imipenem (except MRSA and mycoplasma are resistant)
48
Imipenem is what class of B-lactam, and is always coadministered with _______?
Carbapenems, cilistatin (to prevent rapid renal clearance of drug)
49
What are some non-B-lactam antibacterials that prevent cell wall synthesis?
Vancomycin (covers all Gram +), Bacitracin (covers multi drug resistant Gram - )
50
Name two non-B-lactams that disrupt cell membranes.
Bacitracin, Daptomycin (active against MRSA and VRE)
51
How does Daptomycin disrupt bacterial cell membranes?
It inserts into the membrane and comes together to form a pore that ions freely pass through
52
What drug MUST be administered topically?
Bacitracin, because another route is high enough concentration to cause kidney damage

NBDE Part II (13 decks)

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