Antimicrobials Flashcards Preview

Bacteriology Exam 3 > Antimicrobials > Flashcards

Flashcards in Antimicrobials Deck (38):
1

Cephalosporin

B-lactam

2

Are B-lactams bacter0istatic or bactericidal?

Bactericidal

3

B-lactams are _____-dependent and need frequent dosing

Time

4

Chelating agents

Tetracyclines

5

What Staph gene makes it resistant to B-lactams?

Mec A gene

6

Inhibits peptidoglycan synthesis by stimulating autolysins

B-lactams

7

How does Mec A make Staph resistant to B-lactams?

Alteration in penicillin binding proteins

8

Do not mix _____ and penicillin in the same syringe

Aminoglycosides

9

Anaphylactic reaction (type I HS) possible

B-lactams

10

Widely used in ruminants and swine

Tetracyclines

11

Inhibits protein synthesis by binding to 30s ribosome

Tetracyclines, Aminoglycosides

12

Are tetracyclines bacteriostatic or bactericidal?

Bacteriostatic

13

Tetracyclines are _____-dependent

TIme

14

Cross placental barrier

Tetracyclines

15

Cardiovascular effects (IV in horses = CV collapse)

Tetracyclines (IV doxycycline)

16

Erythromycin

Macrolide

17

Degrade peptidoglycan

Autolysins

18

Are aminoglycosides bacteriostatic or bactericical?

Bactericidal

19

Are aminoglycosides used for anaerobes?

No - need oxygen to function

20

Synthetic antimicrobial agent

Fluorouinolones

21

Inhibit DNA gyrase (DNA replication)

Fluoroquinolones

22

Inhibit nucleic acid synthesis pathway

Sulfa drugs

23

Azithromycin

Macrolide

24

Fluoroquinolones are _____-dependent

Concentration

25

Are fluoroquinolones bacteriostatic or bactericidal?

Bactericidal

26

Rapid resistance development

Fluoroquinolones

27

What resistance mechanisms have bacteria developed against fluoroquinolones?

Modification/protection of target, decreased permeability, efflux pump

28

Treats articular cartilage dgeneration in young dogs and retinal degeneration incats

Fluoroquinolones

29

Treats canine toxic shock syndrome

Fluoroquinolones

30

Synergistic with diaminopyrimidines

Sulfa drugs

31

Inhibit protein synthesis at the 50s ribosome subunit

Macrolides

32

Are macrolides bacteriostatic or bactericidal?

Bacteriostatic

33

Penicillins

B-lactams

34

Immunomodulatory effect

Macrolides

36

Clarithromycin

Macrolide

37

Cabapenem

B-lactam

37

Good oral absorption

Sulfa drugs

38

Resistance by impaired drug penetration, altered enzymes

Sulfa drugs