Antimicrobials II Flashcards Preview

Board Review - B - Systems Pharmacology > Antimicrobials II > Flashcards

Flashcards in Antimicrobials II Deck (46)
1

imipenem

carbapenem

2

meropenem

carbapenem

3

ertapenem

carbapenem

4

doripenem

carbapenem

5

combo of imipenem

administered with cilastatin

inhibit renal dehydropeptidase I

6

cilastatin

inhibit renal dehydropeptidase I

administered with imipenem

7

coverage of carbapenems

broad coverage

used for very sick septic patient

no MRSA coverage

8

aztreonam

monobactam

inhibit peptidoglycan cross-linking
-bind penicillin binding protein 3

synergistic with aminoglycosides

usually nontoxic - little adverse effect

9

coverage of aztreonam

gram negative rods only

no activity - gram positive or anaerobes

10

vancomycin

inhibit cell wall peptidoglycan formation
-binding D-ala - D-ala portion

11

coverage vancomycin

gram positive only

MRSA
staph epidermidis
c. dif

12

red man syndrome

with vancomycin

histamine rlease

13

tx red man syndrome

stop vanco
-start antihistamine

14

adverse vancomycin

red man syndrome

nephrotoxic
ototoxic
thrombophleblitis

15

resistance with vancomycin

alter D-ala-D-ala > D-ala D-lac

16

bacterial ribosome

70S

subunits - 30S and 50S

17

human ribosome

80S

subunits - 40S and 60S

18

buy AT 30, CCEL at 50

protein synthesis inhibitor antibiotics

30S
aminoglycoside
tetracycline

50S
chloramphenicaol
clindamycin
erythromycin
linezolid

19

gentamicin

aminoglycoside - 30S

20

neomycin

aminoglycoside - 30S

21

amikacin

aminoglycoside - 30S

22

tobramycin

aminoglycoside - 30S

23

streptomycin

aminoglycoside - 30S

24

aminoglycosides

30S inhibitor

require O2 for uptake - no coverage anaerobes

25

coverage aminoglycosides

severe gram negative
-synergistic with beta-lactam antibiotics

26

bowel surgery

neomycin

27

resistance to aminoglycosides

bacterial transferase enzyme

acetylation, phosphorylation, adenylation

28

tetracycline

bind 30S
-prevent attachment aminoacyl-tRNA

29

doxycycline

tetracycline

30

minocycline

tetracycline

31

don't take with milk or antacids

tetracyclines

divalent cation - inhibit drug absorption in gut

32

adverse tetracycline

discolor teeth
CI in pregnancy
inhibit kid bone growth
GI distress

33

coverage of tetracyclines

VACUUM THe BedRoom

vibrio
acne
chlamydia
ureaplasma urealyticum
mycoplasma

tularemia
h. pylori

borrelia borgdorferi
rickettsia

34

VACUUM THe BedRoom

coverage of tetracyclines

vibrio
acne
chlamydia
ureaplasma urealyticum
mycoplasm

tularemia
h. pylori

borrelia burgdorferi
rickettsia

35

chloramphenicol

block 50S subunit

36

gray baby syndrome

with chloramphenicol
-infant lack UDP-glucuronyl transferase

37

lack of UDP glucuronyl transferase

gray baby syndrome
-with cholramphenicol

38

adverse cholramphenicol

gray baby syndrome
anemia

39

resistance chloramphenicol

plasmid encoded acetyltransferase - inactivates drug

40

coverage chloramphenicol

meningitis - h. flu, n. meningitis, strep pneum

rocky mountain spotted fever - rickettsia rickettsii

41

clindamycin

block peptide transfer - 50S

42

adverse clindamycin

C. dificile overgrowth
-pseudomembranous colitis

43

treat anaerobe above diaphragm

clindamycin

44

treat anaerobe below diaphragm

metrondiazole

45

linezolid

inhibit protein synthesis
-bind 23S RNA of 50S subunit

46

coverage of linezoli

MRSA and VRE

allow outpatient tx of these infections - because give oral