ANTIPLATELET/ANTICOAGULANT

Question 1

anticoagulant drugs

Answer 1

warfarin, heparin, dabigatran, low-molec-weight heparin

Question 2

antiplatelet drugs

Answer 2

clopidogrel, ticlopidine, dypyridamole, aspirin

Question 3

anticoagulant actions

Answer 3

interfere with coagulation cascade & thrombin formation; DVT/PE

Question 4

antiplatelet actions

Answer 4

targets platelets directly; decrease platelet responsiveness=alter formation of platelet plug; TIA/MI/stroke

Question 5

warfarin

Answer 5

stops cascade from happening at all, PO, taken for longer amt of time, CHEAP

Question 6

heparin

Answer 6

binds to antithrombin III, prevents fibrinogen to fibrin; STRONG/CHEAP/FAST ACTING, injected; more targeted, short term

Question 7

dabigatran

Answer 7

reversibly blocks active site of thrombin; expensive, could be alternative to warfarin

Question 8

LMWH

Answer 8

similar to heparin but can self inject at home, EXPENSIVE

Question 9

clopidogrel and ticlopidine

Answer 9

irreversibly inhibit the binding of ADP to platelets (which inhibits the receptors req’d for platelets to bind to stuff);
admin following MI, TIA, stroke

Question 10

dipyridamole

Answer 10

coronary vasodilation; decreases thromboxane (decrease in platelet stickiness); prophylactic tx of angina pectoris

Question 11

ASA

Answer 11

inhibits COX-1, reduces prostaglandin and thromboxane; prophylaxis/tx to reduce MI, cerebral ischemia