Antiprotozoals and antihelminthes Flashcards Preview

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Flashcards in Antiprotozoals and antihelminthes Deck (19):
1

drug used to tx toxoplasmosis (protozoa)

Pyrimethamine 

2

Pyrimethamine 

drug used to tx toxoplasmosis (protozoa)

3

drug used to tx Trypanosoma brucei (protozoa)

suramin and melarsoprol  

4

suramin and melarsoprol  

drug used to tx Trypanosoma brucei (protozoa)

5

Drug used to tx T. cruzi (protozoa)

nifurtimox 

6

nifurtimox 

Drug used to tx T. cruzi (protozoa)

7

drug used to tx leishmaniasis (protozoa)

sodium stibogluconate 

8

sodium stibogluconate 

drug used to tx leishmaniasis (protozoa)

9

MOA of chloroquine

Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia 

10

Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia 

MOA of chloroquine

11

Use of chloroquine

  • Treatment of plasmodial species other than P. falciparum (frequency of resistance in P. falciparum is too high).
  • Resistance due to membrane pump that decrease intracellular concentration of drug.
  • Treat P. falciparum with artemether/lumefantrine or atovaquone/proguanil.
  • For life-threatening malaria, use quinidine in U.S. (quinine elsewhere) or artesunate. 

12

  • Treatment of plasmodial species other than P. falciparum (frequency of resistance in P. falciparum is too high).
  • Resistance due to membrane pump that decrease intracellular concentration of drug.
  • Treat P. falciparum with artemether/lumefantrine or atovaquone/proguanil.
  • For life-threatening malaria, use quinidine in U.S. (quinine elsewhere) or artesunate. 

Use of chloroquine

13

toxicity of chloroquine

Retinopathy; pruritus (especially in dark-skinned individuals). 

14

Retinopathy; pruritus (especially in dark-skinned individuals). 

toxicity of chloroquine

15

antihelminthic drugs

Mebendazole, pyrantel pamoate, ivermectin, diethylcarbamazine, praziquantel 

16

Mebendazole, pyrantel pamoate, ivermectin, diethylcarbamazine, praziquantel 

antihelminthic drugs

17

use of antihelminthic drugs

immobilize helminths 

18

use of praziquantel 

against flukes (trematodes) such as Schistosoma 

19

against flukes (trematodes) such as Schistosoma 

use of praziquantel