Antipsychotic Agents & Lithium Flashcards Preview

Pharmacology II > Antipsychotic Agents & Lithium > Flashcards

Flashcards in Antipsychotic Agents & Lithium Deck (18):
1

Examples of positive symptoms of Schizophrenia

-hallucinations
-conceptual disorganization
-Unusual thought content

2

Examples of negative symptoms of Schizophrenia

-Anhedonia
-Avolition
-Alogia
-Flattened affect

3

Which antipsychotic drug is associated with QTc prolongation?

Thioridazine (1st gen)

4

Which antipsychotic drug was made first and is associated with weight gain?

Chlorpromazine (1st gen)

5

Which two second generation antipsychotics need to be taken with food?

Lurasidone and Ziprasidone

6

Which second gen antipsychotic is associated with altered blood counts?

Clozapine (so check plasma levels before exceeding 600mg)

-Agranulocytosis
-Sialorrhea (excess drooling)

7

Pharmacokinetics of antipsychotics

-well absorbed
-lipid soluble
-extensively protein bound
-metabolized by liver
-Long plasma half-lives

8

What is haloperidol often paired with right off the bat to hopefully avoid extrapyramidal side effects?

Benztropine (antimuscarinic)

9

What are the goals of treatment of schizophrenia in the first week?

-decreased agitation, hostility, anxiety, aggression
-normalization of sleep and eating

10

How long should antipsychotic medication be continued after the first psychotic episode?

at least 12 months

11

When stopping antipsychotics, esp clozapine, what is important to remember?

taper slowly to avoid cholinergic rebound (1-2 week taper)

12

Lithium indication

-treat the manic phase in Bipolar disorder
-Lithium has slow onset

13

When taking lithium, what electrolyte must be monitored?

Sodium (Na+)


(lithium replaces sodium in the body)

14

Lithium: MOA

-reduces excitatory neurotransmitters like glutamate and dopamine

-increases inhibitory neurotransmission (GABA)

15

Lithium: metabolism and excretion

-No metabolism
-Excreted entirely in urine

16

Lithium: pharmacokinetics

-Clearance decreased by thiazides and NSAIDs

so, will Lithium will have greater effect

17

Lithium toxicities

-hypothyroidism
-Pregnancy category D

18

Lamotrigine: ADE

rash