Antiseizure Flashcards Preview

Unit 4 > Antiseizure > Flashcards

Flashcards in Antiseizure Deck (16)
1

What are the Na channel blockers of antiepileptic drugs?

Carbamazepine/phenytoin/lamotrigine (block glutamate receptor too)

2

What are the 2 common glutamate receptors and what are their characteristics?

NMDA and AMPA
Weak stimulation activate AMPA first--->NMDA is blocked by Mg2+--->strong stimulation kick off Mg2+ and activate NMDA

3

Which 2 drugs block NMDA and AMPA? and what are they used for?

Felbamte blocks NMDA
Topiramate blocks AMPA
Antiepileptic

4

What drugs block presynaptic Ca2+ channels and thus have antiepileptic affect?

Ethosuximide/gabapentin

5

What is DOC for absence seizure?

Ethosuximide

6

What is used for status epilepticus?

IV benzo

7

If a pt has absence seizure and partial complex seizure, what drug should be given?

Valproic acid (absence + something else = valproic acid)

8

What are the side effects of phenytoin?

Gingival hyperplasia
Hirsutism
Osteomalacia (interferes with Vitamin D metabolism)
Teratogen--->cleft lip and palate

9

What is carbamazapine used for besides antiepileptic? side effects?

DOC for trigeminal neuralgia (aka tic douloureux)--->intense facial pain
Bipolar

Side effects:
Megaloblastic anemia
Aplastic anemia
Increase ADH secretion--->hyponatremia
Stevens-Johnson syndrome
teratogen like phenytoin

10

What else is valproic acid used for? side effects?

Mania of bipolar
Mirgraine prophylaxis

Side effect:
Hepatotoxicity (especially for spina bifida

11

Side effect of lamotrigine?

Stevens-Johnson syndrome

12

What is levetiracetam used for?

Focal onset and generalized tonic-clonic seizures

13

What is the side effect of felbamate that limit its use?

Aplastic anemia

14

What else does cabapentin used for?

Neuropathic pain like postherpetic neuralgia

15

What happens if you abruptly withdraw antiepileptics?

Precipitate seizures

16

List 3 antiepileptics that would decrease efficacy of oral contraceptives

Phenytoin/carbamazepine/phenobarbital (CYP450 inducer)