Flashcards in Antiseizure Deck (16)
What are the Na channel blockers of antiepileptic drugs?
Carbamazepine/phenytoin/lamotrigine (block glutamate receptor too)
What are the 2 common glutamate receptors and what are their characteristics?
NMDA and AMPA
Weak stimulation activate AMPA first--->NMDA is blocked by Mg2+--->strong stimulation kick off Mg2+ and activate NMDA
Which 2 drugs block NMDA and AMPA? and what are they used for?
Felbamte blocks NMDA
Topiramate blocks AMPA
What drugs block presynaptic Ca2+ channels and thus have antiepileptic affect?
What is DOC for absence seizure?
What is used for status epilepticus?
If a pt has absence seizure and partial complex seizure, what drug should be given?
Valproic acid (absence + something else = valproic acid)
What are the side effects of phenytoin?
Osteomalacia (interferes with Vitamin D metabolism)
Teratogen--->cleft lip and palate
What is carbamazapine used for besides antiepileptic? side effects?
DOC for trigeminal neuralgia (aka tic douloureux)--->intense facial pain
Increase ADH secretion--->hyponatremia
teratogen like phenytoin
What else is valproic acid used for? side effects?
Mania of bipolar
Hepatotoxicity (especially for spina bifida
Side effect of lamotrigine?
What is levetiracetam used for?
Focal onset and generalized tonic-clonic seizures
What is the side effect of felbamate that limit its use?
What else does cabapentin used for?
Neuropathic pain like postherpetic neuralgia
What happens if you abruptly withdraw antiepileptics?