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Flashcards in Antithrombotic agents Deck (63)
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1

Anticoagulant agents drug of choice for prevention/treatment of _____ and prevention of _____ in patients with _____

venous thromboembolism
Cardioembolic event with atrial fibrillation
(Also can use for arterial thrombosis + antiplatelet)

2

anti-platelet agents drug of choice for prevention/treatment of ___

arterial thrombosis (primary/secdonary prevention of ACS)

3

Primary prevention with risk factor - give

aspirin

4

primary prevention with no risk factors - give

aspirin (men>45, women>65)

5

Secondary prevention with recent MI - give ___

aspirin (clopidogrel)

6

Secondary prevention with ischemic stroke - give ___

aspirin +/- clopidogrel

7

Unstable angina - give

aspirin
+/- clopidogrel/prasugrel/ticagrelor, UFH/LMWH/fondaparinux, GPIIb/IIIa inhibitor

8

NSTEMI - give ___

aspirin
+/- clopidogrel/prasugrel/ticagrelor, UFH/LMWH/fondaparinux, GPIIb/IIIa inhibitor

9

STEMI (aka ___) - give

acute MI
aspirin
+/- clopidogrel/prasugrel/ticagrelor, UFH/LMWH/FONDAPARINUX, GPIIb/IIIa inhibitor

10

Peripheral critical ischemia - give __

aspirin
+/- clopidogrel/prasugrel/ticagrelor, UFH/LMWH/BIVALIRUDIN, GPIIb/IIIa inhibitor

11

Atrial Fibrillation - give ___

Warfarin/Dabigatran/rivaroxaban/apixaban
Low risk = aspirin

12

GP1a bind to ___

collagen

13

GP1b bind to ___

GPIIb/IIIa + vWF

14

GPIIb/IIIa bind to ___

fibrinogen

15

aPTT = aka + ref range

activated partial thromboplastin time; 26-33 sec

16

prolonged aPTT indicates defects in ____ pathway and used to monitor ___ therapy

intrinsic
Heparin
(note: aPTT not affected by LWMH)

17

PT = aka + ref reange

prothrombin time/ 12-14 sec

18

prolonged PT = defect in ___ pathway, used to monitor ___ therapy based on ___

extrinsic
warfarin
INF (international normalized ratio)

19

Ecarin clotting time (ECT) uses ecarin derived from ___

venom of saw-scaled viper

20

ECT prolonged = increasing concentration of ___ or ___ in plasma; used to monitor anticoagulant therapy with _______

hirudin/dabigatran
Direct thrombin IIa inhibitors

21

Fibrinolysis central process is the activation of ____ to _____ by ___

plasminogen --> plasmin by tPA

22

plasmin _________

proteolyzes fibrin/limits thrombosis

23

Fibrin inhibition by _____ and _____

antithrombin III (accelerated by heparin)
Protein C (Ccofactor protein S)

24

Protein C inactivates: _____ and ____

Va, VIIIa

25

Unfractionated heparin binds to ____ and _____

antithrombin III and
IIa, Xa, (IX, XI, XII, XIII)

26

Enoxapirin is a ____

LMWH

27

LMWH binds to ___

Xa only (not IIa)

28

Fondaparinux is a ______ binds to __

pentasaccharide activator of ATIII, inactivates Xa only

29

Argatroban is a ___

direct thrombin IIa inhibitor

30

Bivalirudin is a ___

direct thrombin IIa inhibitor