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Unit 4 > Antithyroid > Flashcards

Flashcards in Antithyroid Deck (20)
1

What is the process of thyroidglobulin synthesis?

Iodide is taken into the cell---(thyroid peroxidase)--->iodine--(organification)-->MIT and DIT--(coupling)-->T3/T4

2

How is 131 I used? When shouldn't we use it?

Beta radiation of 131 I--->destruction of thyroid
Avoid young kids and pregnancy

3

What drugs block thyroid peroxidase and thus treat hyperthyroidism?

PTU/methimazole/carbimazole

4

What drugs block deiodinase (convert T4 to T3)

Propranolol and PTU

5

What is the side effect of PTU/methimazole/carbimazole? and why is methimazole is used more than PTU now?

Agranulocytosis
Because PTU can cause liver failure

6

Which drug is used for hyperthyroidism in pregnant women? why?

PTU
PTU is highly protein bound--->unlikely to cross placenta

7

What are the synthetic T4 and T3 and which one is used for acute hypothyroidism?

T4-->levothyroxine
T3--->liothyroxine
Liothyroxine is used for acute condition

8

What is Lugol solution and what is it used for? and what is its disadvantage?

Potassium iodide + iodine--->for thyrotoxicosis
It stops working after 10-14 days

9

What are the synthetic ADH and ACTH?

ADH--->demopressin
ACTH--->cosyntropin

10

What are the 2 drugs that can be used for hyperprolactinemia?

Bromocriptine and cabergoline

11

How to distinguish central and nephrogenic diabetes insipidus?

Give desmopressin--->if response to it--->central
If not--->nephrogenic

12

What else can desmopressin be used for?

Hemophilia A/vW disease/nocturnal enuresis

13

MOA of octreotide/usage/side effect?

Somatostatin analog
Carcinoid tumor/acromegaly/bleeding varices
Gallstone

14

What level would increase in pt with acromegaly?

GH and IGF-1

15

What drugs are used to treat SIADH and what are their MOA?

Block V2 receptor in collecting duct
Demeclocycline and tolvaptan

16

What drugs can cause SIADH?

Vincristine/vinblastine/carbamazepine

17

What are the bisphosphonates/MOA/their usage?

"dronate"--->reduce osteoclast activity--->treat osteoporosis/Paget's disease

18

What is the side effect of bisphophonate and how do we prevent it?

Esophageal irritation/ulcers--->taking the drug sitting upright and fasting for 30min
Osteonecrosis of the jaw as well

19

Which drug is the only drug that can stimulate new bone formation? usage and side effect?

Teriparatide--->PTH analog--->osteoporosis
Increase risk for osteosarcoma

20

What is cinacalcet's MOA/usage?

Reduce PTH and Ca level--->secondary hyperPTH from renal disease