Flashcards in Antithyroid Deck (20)
What is the process of thyroidglobulin synthesis?
Iodide is taken into the cell---(thyroid peroxidase)--->iodine--(organification)-->MIT and DIT--(coupling)-->T3/T4
How is 131 I used? When shouldn't we use it?
Beta radiation of 131 I--->destruction of thyroid
Avoid young kids and pregnancy
What drugs block thyroid peroxidase and thus treat hyperthyroidism?
What drugs block deiodinase (convert T4 to T3)
Propranolol and PTU
What is the side effect of PTU/methimazole/carbimazole? and why is methimazole is used more than PTU now?
Because PTU can cause liver failure
Which drug is used for hyperthyroidism in pregnant women? why?
PTU is highly protein bound--->unlikely to cross placenta
What are the synthetic T4 and T3 and which one is used for acute hypothyroidism?
Liothyroxine is used for acute condition
What is Lugol solution and what is it used for? and what is its disadvantage?
Potassium iodide + iodine--->for thyrotoxicosis
It stops working after 10-14 days
What are the synthetic ADH and ACTH?
What are the 2 drugs that can be used for hyperprolactinemia?
Bromocriptine and cabergoline
How to distinguish central and nephrogenic diabetes insipidus?
Give desmopressin--->if response to it--->central
What else can desmopressin be used for?
Hemophilia A/vW disease/nocturnal enuresis
MOA of octreotide/usage/side effect?
Carcinoid tumor/acromegaly/bleeding varices
What level would increase in pt with acromegaly?
GH and IGF-1
What drugs are used to treat SIADH and what are their MOA?
Block V2 receptor in collecting duct
Demeclocycline and tolvaptan
What drugs can cause SIADH?
What are the bisphosphonates/MOA/their usage?
"dronate"--->reduce osteoclast activity--->treat osteoporosis/Paget's disease
What is the side effect of bisphophonate and how do we prevent it?
Esophageal irritation/ulcers--->taking the drug sitting upright and fasting for 30min
Osteonecrosis of the jaw as well
Which drug is the only drug that can stimulate new bone formation? usage and side effect?
Increase risk for osteosarcoma