Antiviral #2 Flashcards Preview

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Flashcards in Antiviral #2 Deck (11):
1

Zidovudine

Mechanism: NRTI , thymidine analog

Main Toxicity: Bone marrow toxicity and GI intolerance

2

Didanosine

Mechanism: NRTI, purine nucleoside

Main Toxicity: Peripheral neuropathy, pancreatitis, GI intolerance

3

Lamivudine

Mechanism: NRTI

Main Toxicity: low toxicity, nasal congestion, nausea, malaise, fatigue, flare of Hep B

4

Abacavir

Mechanism: NRTI, nucleoside analog

Main Toxicity: Severe HS rxn

5

Emtricitabine

Mechanism: NRTI,

Main Toxicity: minimal toxicity, hyperpigmentation of palms and soles

6

Tenofovir

Mechanism: NRTI

Main Toxicity: GI intolerance, renal toxicity

7

Efavirenz

Mechanism: NNRTI, p-450 metabolism

Main Toxicity: Rash, dizziness, HA, insomnia, neural tube defects

8

Ritonavir

Mechanism: PI, p-450 enzyme, inhibits gal-pol polyprotein

Main Toxicity: GI, circumoral and peripheral paraesthesia, aminotransferase increase

9

Indinavir Sulfate

Mechanism: PI, p-450, inhibit HIV protease

Main Toxicity: GI, nephrolithiasis, hyperbilirubinemia, Derm changes

10

Nelfinavir mesylate

Mechanism: PI, P-450

Main Toxicity: GI, N/V/D

11

Atazanavir

Mechanism: PI

Main Toxicity: GI, abnormal fat distribution, increase aminotransferase