Antivirals Flashcards Preview

Pharma > Antivirals > Flashcards

Flashcards in Antivirals Deck (67):
0

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

Acyclovir

1

Inhibits viral RNA polymerase, DNA polymerase and HIV reverse transcriptase

Foscarnet

3

Acyclovir has no activity against strains of HSV with absent _

Thymidine kinase activity

4

For HSV infection in patients with AIDS

Foscarnet

5

Anti-HSV that inhibits fusuon between HSV envelope and plasma membranes

Docosanol

7

Uses of acyclovir

HSV 1 and 2
VZV

8

Binds to pyrophosphate binding site

Foscarnet

9

Causes nephrotoxicity (cystalluria)

Acyclovir

10

Inhibits viral DNA polymerase. Do not need thymidine kinase.

Ganciclovir
Cifodovir

12

Uses of ganciclovir

HSV 1 and 2
VZV
CMV

13

SE of cifoduvir

Nephrotoxicity

14

Causes leukopenia, trombocytopenia and neutropenia

Ganciclovir

15

For CMV retinitis

Cifodovir
Foscarnet

16

Causes electrolyte abnormality

Foscarnet (hypocalcemia)

17

Inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes

Zidovudine (NRTI)

18

Inhibit HIV reverse transcriptase without requiing phosphorylation

Delavirdine (NNRTI)

19

For prevention of maternal-fetal HIV transmission

Zidovudine (NRTI)
Give to mother prior and during delivery
Give to baby after delivery

20

Causes lactic acidosis with hepatic steotosis

NRTI

21

NRTI that causes bone marrow suppression

Zidovudine

22

NRTI that causes hypersensitivity

Abacavir

23

NRTI that causes pancreatitis

Didanosine

24

NRTI that causes peripheral neuropathy

Stavudine
Zalcitabine

25

NNRTI that causes rash, inc AST/ALT

Delavirdine
Nevirapine

26

NNRTI with teratogenicity

Efavirenz

27

NNRTI with inc cholesterol and triglycerides

Etravirine

28

Noncompetitive inhibitors of reverse teanscriptase

NNRTI

29

Reverse transcriptase inhibitors that do not incorporate in chain

NNRTI

30

Inhibit movement of reverse transcriptase

NNRTI

31

Analogue of deoxynucleotides. Incorporate in growing DNA chain

NRTI

32

Protease inhibitor

Indinavir

33

Fusion inhibitor

Enfuvirtide

34

CCR5 receptor antagonist

Maraviroc

35

For influenza A

Amantadine

37

Inhibit viral processing

Indinavir

38

Enfuvirtide binds to _ subunit of viral envelop preventing fusion of viral and cellular membranes

Gp41

39

Causes fat redistribution, hyperglycemia, hyperlipidemia, insulin resistance

Protease inhibitors

40

Binds to gp41 subunit of viral envelop preventing fusion of viral and cellular membranes

Enfuvirtide

41

Prevents viral uncoating

Amantadine

43

Blocks viral attachment via transmembrane chemokine receptor CCR5

Maraviroc

44

No cross-resistance with other anti-HIV drugs

Enfuvirtide

45

Minimal cross-resistance with other anti-HIV drugs

Maraviroc

46

SE of indinavir

Hyperbilirubinemia and nephrolithiasis

47

SE of amprenavir

Rash

48

Causes cerebellar dysfunction

Amantadine

49

Inhibits guanosine triphosphate formation

Ribavirin

50

SE of atazanavir

Peripheral neuropathy

51

For influenza A and B

Oseltamivir

52

SE of saquinavir

GI distress and diarrhea

53

SE of oseltamivir

GI effects

55

SE of zanamivir

Bronchospasm in asthmatics

56

Presently the DOC for influenza

Oseltamivir

57

Uses of amantadine

Influenza A
Rubella

58

Blocks RNA-dependent RNA polymerases

Ribavirin

59

Causes livedo reticularis

Amantadine

60

Inhibits neuraminidase

Oseltamivir

61

Amantadine prevents uncoating by binding to _

M2 proton channels

64

Prevents capping of mRNA

Ribavirin

65

For hep B

Interferon a
Lamivudine

67

Use of lamivudine for HBV HCV coinfection can increase risk for _

Pancreatitis

69

Degrades viral RNA via activation of host cell RNAse

Interferon a

70

Use of interferon a

HBV
HCV
Kaposi sarcoma
Genital warts

71

Contraindications of interferon a

Autoimmune disease
Cardiac arrhythmia
Pregnancy

72

Uses of lamivudine

HBV
HIV

73

SE of adefovir

Lactic acidosis
Renal and hepatic toxicity

74

Use of ribavirin

HCV
RSV

75

Early administration decreases mortality in viral helorrhagic fevers

Ribavirin

76

SE of entecavir

Headache
Dizziness
Fatigue
Nausea