Anxiety and Insomnia Flashcards
1
Q
Zolpidem
A
Selective for alpha1 of GABAa receptors
Sedation
Non-benzo
3-6 hours
2
Q
Melatonin
A
Sleep
M1 and M2 receptors, GPCRs
3
Q
Suvorexant
A
Orexin receptor antagonist
Next day sedation, abuse potential
Short term use only
4
Q
Do orexin receptors promote sleep or wake?
A
Wake
5
Q
Temazepam
A
Short acting benzodiazepine, rapid onset
6
Q
Alprazolam
A
Short acting benzodiazepine, rapid onset
7
Q
Nitrazepam
A
Long acting benzodiazepine, 16-40 hours, not rapid onset
8
Q
Diazepam
A
Long acting benzodiazepine, 20-90 hours
9
Q
Which 5HT receptors are involved in anxiety?
A
1A, 1C, 2A, 4
10
Q
Buspirone
A
5HT-1A receptor partial agonist
Somato-dendritic -ve feedback of 5HT release
11
Q
Nefazodone
A
SARI, good for sleep and anxiety, reduced sexual dysfunction.
12
Q
RIMA
A
Moclobemide
13
Q
MAOI
A
Tranylcypromine
14
Q
SARI
A
Nefazodone
