Anxiety and Sleep pharmacology Flashcards Preview

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Flashcards in Anxiety and Sleep pharmacology Deck (27):
0

Part of the brain that signals that a threat is present and triggers a fear response or anxiety and has a role in storage of emotional memories

amygdala

1

Portion of the brain that processes incoming stimuli and encodes it into memories

hippocampus

2

Mechanism of action of buspirone

5HT1A receptor partial agonist

3

Mechanism of action of benzodiazepines

enhance the response of GABA by facilitating the opening of GABA-A receptors

4

GABA-A subunits required for GABA binding

alpha and beta

5

GABA-A subunits required for BZD binding

alpha and gamma

6

Ion that travels through GABA-A channels

Chloride

7

5 BZDs used in insomnia

1. Triazolam
2. Temazopam
3. Quazepam
4. Estazolam
5. Furazolam

8

3 novel BZD receptor agonists

1. Zalepion
2. Zolpidem
3. Eszzopiolone

9

GABA subunit that is important for sedative and amnesia effects of BZDs

alpha-1

10

GABA receptor that is important for the anxiolytic effects of BZDs

alpha-2

11

BZD antagonist that is used clinically to reverse sedative action of BZDs in acute overdose or when used during anesthesia

Flumazenil

12

area of the brain that controls circadian rhythm

suprachiasmatic nucleus (SCN) in the hypothalamus

13

Small portion of the brain where melatonin is synthesized

pineal gland

14

specialized secretory cells that secrete meletonin

pinealocytes

15

The precursor of melatonin

tryptophan

16

Mechanism of action of ramelteon

melatonin receptor (MT1 and MT2) antagonist

17

Mechanism of action of diphenhydramine and doxylamine

H1 histamine receptor antagonists

18

Location of the brain where histamine is produced

tuberomammillary nucleus in the posterior hypothalamus

19

Precursor of histamine

Histadine

20

TCA that is FDA approved for insomnia characterized by sleep maintenance difficulty

Doxepin

21

CNS depressant that may be used for insomnia

Chloral hydrate

22

Active metabolite of chloral hydrate that gives its sedative effects

triclorothanol

23

Neurons that are lost in patients with narcolepsy

orexin neurons

24

Medication that is an orexin receptor (OX1 and OX2) antagonist

Suvorexant

25

The best established pathway for reinforcement

the dopaminergic projection from the ventral tagmental area (VTA) to the nucleus accumbens

26

Where cell bodies of dopiminergic neurons originate from

Ventral tagmental area (VTA)