AP/AD side effects

Question 1

TCAs in general

Answer 1

sedation, anticholernergic, prolonged QT, weight gain

Question 2

MOAis in general

Answer 2

hypertensive/serotonin crisis, orthostatic hypotension, sexual dyfunction, weight gain

Question 3

SSRIs in general

Answer 3

agitation, insomnia, sexual dysfunction,

Question 4

sertraline specific

Answer 4

nausea

Question 5

paroxetine specific

Answer 5

sedation, bad withdrawal

Question 6

citalopram specific

Answer 6

prolonged QT, interacts with PPI in elderly

Question 7

SNRI in general

Answer 7

noradrenergic, nausea on start, withdrawal syndrome

Question 8

venlafaxine specific

Answer 8

dose dependant hypertension

Question 9

nefazodone specific

Answer 9

small risk of liver dysfunction

Question 10

trazodone specific

Answer 10

sedation, priapism

Question 11

bupropion

Answer 11

stimulant, dose related risk of seizures, risk of eating disorders

Question 12

mirtzapine

Answer 12

very sedating, weight gain

Question 13

paraxone/ fluoxetine can reduce effect of

Answer 13

makes less effective: tamoxifen, codine (any prodrugs)

Question 14

fluvoxamine can increase effect of

Answer 14

caffiene, clozapine

Question 15

SSRI/SNRI can cause bleeding with

Answer 15

warfarin, NSAIDS, aspirin

Question 16

typical APs in general

Answer 16

extrapyrimidal SE, endocrine disturbances, edema and weight gain, sedation, convulsions in epileptics,

Question 17

chlorpromazine specific

Answer 17

sedation, autonomic sx worse

Question 18

thioridazine

Answer 18

sedation, autonomic sx worse

Question 19

loxapine

Answer 19

higher extrapyramidal effects

Question 20

molindone

Answer 20

higher sedation and extrapyramidal

Question 21

thiothixene

Answer 21

high extrapyramidal effects

Question 22

fluphenazone

Answer 22

very high high extrapyramidal effects

Question 23

haldol

Answer 23

very high extrapyramidal effects

Question 24

typical ADs interact with

Answer 24

increase effects of CNS depressants, reduce L-Dopa, increase anticholenergic effects of TCA

Question 25

atypical APs in general

Answer 25

possible diabetes, weight gain, extrapyrimidal, endocrine

Question 26

cloazpine

Answer 26

AGRANULOCYTOSIS, de novo seizures, salaivation,

Question 27

risperidone/paliperadone

Answer 27

asthenia, drowsiness, high prolactin, most likely of 2AP to cause extrapyramidal SE

Question 28

olanzapine

Answer 28

extrapyramidal SE, posterural hypotension, constipation and weight gain

Question 29

quetapine

Answer 29

BLACK BOX FOR QTc, tradive dyskinesias

Question 30

ziprasidone

Answer 30

slight QTc, weight loss, transient prolactin

Question 31

ariripirazole

Answer 31

anxiety, headachem n/v, slight extrapyrimdal

Question 32

Lithium SE

Answer 32

polydipsia/polyuria, blunting, decreased thyroid

Question 33

valproic acid

Answer 33

(BLACK BOX hepatic failure, pancreatitis, teratogenic) - other thrombocytopenia

Question 34

carbamazepine

Answer 34

BLACK BOX - problems in Asians, aplastic anemia, agranulocytosis, dermatological tox