arachidonic acid derivative effects + drugs Flashcards Preview

4 star topic: one question on test > arachidonic acid derivative effects + drugs > Flashcards

Flashcards in arachidonic acid derivative effects + drugs Deck (12):
1

drug inhibits lipoxygenase → blocks luekotriene formation

zileuton

2

drug inhibits leukotriene receptor of LTC4, LTD4, LTE4

zafrilukast
montelukast (for young children)

3

drug inhibits phospholipase A2

corticosteroids

4

drugs inhibit COX-1/COX-2

NSAIDs
acetaminophen (inactivate peripheral COX, no anti-PLT or anti-inflammatory effects)
aspirin (irreversible)
celocoxib (COX-2 inhibitor)

5

AA product causes ↑ bronchial tone

LTC4, D4, E4
TXA2

6

AA product causes ↓ bronchial tone

PGI2 (prostacyclin)
PGE2, F2α (prostaglandin)

7

AA product causes ↑ PLT aggregation

TXA2

8

AA product causes ↓ PLT aggregation

PGI2 (prostacyclin)

9

AA product causes ↑ uterine tone

PGE2, F2α (prostaglandin)

10

AA product causes ↓ uterine tone

PGI2 (prostacyclin)

11

AA product causes ↑ vascular tone

TXA2

12

AA product causes ↓ vascular tone

PGI2 (prostacyclin)
PGE2, F2α (prostaglandin)