arthritis Flashcards

1
Q

__ and __ are cytokines that can trigger infalmmmatory cascades

A

IL1 and TNF - have ligands for integrins

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2
Q

gout caused by…

A

decreased excretion

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3
Q

RA considered a—

A

erosive arthritis

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4
Q

chronic RA includes.. formation

A

pannus; vascularized erosion?

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5
Q

pannus is

A

membrane of granulation tissue from mesenchyme and bone marrow derived cells

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6
Q

ACPA or anti CCP best test and

A

associate with HLADRB1 and smoking

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7
Q

how does MTX work?

A

its a dihydrofolate reductase inhibitor

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8
Q

RA more likely to affect ___ jt than OA

A

MCP

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9
Q

ankylosing spondylitis

A

HLA B27 gene

exersie NSAIDS and sulfasalazine

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10
Q

risk factor SLE

A

women, African americans, onset when 15-49

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11
Q

theory of SLE problem

A

deficiency in complement pathway that typically breaks down messed up cells

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12
Q

serositis

A

complication of SLE leads to pulm fibrosis and intralveolar hemorrhage

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13
Q

SLE

A

NSAID< hydroxycholorquine, prednisone methotrexate

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14
Q

___ can work for steroid resistant SLE but can cause kidney damage

A

cyclosporine

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