Asthma and Resp

Question 1

What are the 3 categories of resp drugs

Answer 1

Bronchodilators
Anti-Inflammatories
Cough and rhinitis

Question 2

What are the short acting beta 2 agonists

Answer 2

Albuterol
Pirbuterol
Terbutaline
Metaproterenol

Question 3

What are the long acting beta 2 agonists

Answer 3

Salmeterol

Formeterol

Question 4

What are the non-specific beta agonists

Answer 4

Epinepherine

Isoproterenol

Question 5

What is the non-specific beta agonist that is not inhalable

Answer 5

Isoproterenol

Question 6

What is the Methylxanithine derivative

Answer 6

Theophylline

Question 7

What does Theophylline do

Answer 7

PDE inhibitor

Blocks adenosine receptors

Question 8

What are the muscarinic antagonists

Answer 8

Ipratropium

Tiotropium

Question 9

What are the mast cell stabilizers

Answer 9

Cromolyn

Nedocromil

Question 10

What inhaled steroids are used for chronic asthma

Answer 10

Beclomethasone
Fluticasone
Flunisolide
Budesonide

Question 11

What are the IV steroids

Answer 11

Dexamethasone
Prednisolone
Hydrocortisone

Question 12

Which LT antagonist inhibits LOX

Answer 12

Zileuton

Question 13

Which LT antagonist are LTD4 antagonists

Answer 13

Zafirlukast

Montelukast

Question 14

Which resp drug is an antibody

Answer 14

Omalizumab

Question 15

What are the opiods

Answer 15

Codeine

Dextromethorphan

Question 16

What is the Mycolytic agent

Answer 16

N-acetylcysteine (NAC)

Question 17

1st gen H1 antagonists

Answer 17

Diphenhydramine

Chlorpheniramine

Question 18

2nd gen H1 antagonists

Answer 18

Loratadine
Fexofenadine
Cetirizine

Question 19

What are the alpha agonists

Answer 19

Phenylephrine

Pseudoephedrine

Question 20

What is the action of adrenergic agonists

Answer 20

Increase cAMP

Bronchial SM relaxation

Question 21

DOC acute relief of bronchospasms

Answer 21

Short acting beta 2

Question 22

What are long acting beta 2 agonists used mainly for

Answer 22

Prophylaxis

Question 23

What do you give to asthma with anaphylactic shock or when other drugs failed

Answer 23

Epinepherine

Question 24

Which is primarily used in heart block and bradycardia (beta 1)

Answer 24

Isoproterenol

Question 25

Why does inhalation of beta 2 agonists minimize AE

Answer 25

Poor absorption through lungs

Question 26

What are the beta 2 AE

Answer 26

Tremor Tachycardia Arrhythmia Tolerance

Question 27

How does Theophylline cause bronchodilation

Answer 27

Block cAMP metabolism

Question 28

Effect of CYP inducers/inhibitors on Theophylline effect

Answer 28

Inducers decrease | Inhibitors increase

Question 29

Theophylline AE

Answer 29

Seizures and Arrhythmias Tremor, insomnia, GI Hypokalemia Hyperglycemia

Question 30

What is the action of muscarinic antagonists

Answer 30

Block parasympathetics | Decrease bronchoconstriction and mucus secretion

Question 31

When do you give Ipatropium

Answer 31

Drug induced bronchospasm | Tx of Asthma in COPD

Question 32

Ipatropium AE

Answer 32

Dry mouth | Sedation

Question 33

What is the long acting muscarinic antagonist

Answer 33

Tiotropium

Question 34

How do corticosteroids act

Answer 34

Inhibit PLA2 | Bind glucose response elements

Question 35

When are inhaled steroids given

Answer 35

Maintain inflammation supression

Question 36

Given for severe attacks (status asthmaticus)

Answer 36

Systemic steroids

Question 37

What can be used to treat chronic rhinitis

Answer 37

Beclomethasone | Flunisolide

Question 38

Inhaled corticosteroid AE

Answer 38

Cough Oral thrush Dysphonia

Question 39

IV steroid AE

Answer 39

Abnormal glucose metab Increase appetite and weight gain HTN Adrenal supression

Question 40

How do LT antagonists act

Answer 40

Block LT synth or LT receptors | Decrease constriction and inflammation

Question 41

When do you give LT antagonists

Answer 41

Exercise, Ag, or Aspirin-induced asthma | Chronic maintenance

Question 42

What are LT antagonists NOT useful for

Answer 42

Acute bronchospasm

Question 43

Zileuton AE

Answer 43

Increase LFTs

Question 44

Lukast AE

Answer 44

Vasculitis with EOS (similar to Churg-Strauss)

Question 45

How does Omalizumab work

Answer 45

Bind IgE on sensitized mast cells | Prevent mediator release

Question 46

When do you give Omalizumab

Answer 46

Asthma prophylaxis when inhaled corticosteroids don't work (> 12yrs age)

Question 47

What is the AE for Omalizumab

Answer 47

Anaphylaxis

Question 48

How do opioids act as antitussives

Answer 48

Depress CNS cough center sensitivity to peripheral stimuli (low dose)

Question 49

When are opioids administered

Answer 49

Severe cough that disrupts sleep

Question 50

What is the benefit of using Dextromethophan over codeine

Answer 50

No analgesic or addictive potential | Less constipating

Question 51

How does NAC work

Answer 51

Break disulfides in mucus | Easier to cough it out

Question 52

When is NAC administered

Answer 52

CF | Acetaminophen OD

Question 53

When are H1 antagonists administered

Answer 53

Allergic rhinitis

Question 54

What do alpha agonists do

Answer 54

Constrict dilated arterioles

Question 55

How is the alpha agonist effect different when aerosol

Answer 55

Rapid onset | Few systemic side effects

Question 56

When are alpha agonists administered

Answer 56

Rhinitis

Question 57

What is the effect of prolonged alpha agonist use

Answer 57

Rebound nasal congestion after discontinuation