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Flashcards in Asthma guidance & drugs Deck (53)
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1

How should patients used DPI inhalers?

Need to breathe in fast and strong to create enough turbulence to lift the particles

2

Why should Beclometasone CFC-free MDIs (QVAR and CLENIL) have their brand endorsed on prescriptions?

What is the combination inhaler also effected by this?

Because they are not interchangeable:
QVAR has extra fine particles that can reach the lungs faster and quicker therefore its more potent (QVAR is 2 x as potent as Clenil)

FOSTAIR also effected- beclometasone and formeterol - its the same as QVAR- has extra fine particles so more potent

3

Which beta blockers would we be most worried about in asthmatic patients? (5)

Non-cardioselective beta blockers, as these may be more likely to constrict airways:

Propranolol
Sotolol
Labetolol
Carvedilol
Timolol

The cardioselective ones (atenolol, bisoprolol) are less of a worry

4

How should a spacer be cleaned?

Wash it in mild detergent and allow to air dry, wipe mouthpiece free of detergent
Do this once a month (more frequently will effect the electrostatic charge)

5

How often should a spacer be replaced?

Every 6-12 months

6

When would nebuliser adrenaline or budesonide be needed?

Child with severe croup

Not severe: oral beclometasone or prednisolone usually used

7

When should nebulisers be considered in long term management of COPD or asthma?

Remains breathless after two weeks of correctly using optimal therapy

8

What proportion of nebulised drug will reach lungs?

10-30%

Diluent usually used in nebulisers: NaCl 0.9%

9

What ages are spacers recommended in children?

Up till the age of 5 for bronchodilators (saba, labas)
Ages 5-15 for ICS

10

What is the standard length of treatment with steroids for an asthma attack?
Does this differ in children?

Prednisolone oral for 5 days in adult

Prednisolone oral for 3 days in child

IF NBM- IV hydrocortisone every 6 hours until conversion to oral

Can usually abruptly stop the steroid unless the patient has been on oral corticosteroids previously (step 5) for over three weeks

11

What degree of asthma attack should we consider the use of high flow oxygen?

If it's severe

We use SABA (e.g. Salbutamol) nebs plus high flow oxygen

Only Saba nebs needed if moderate

12

If oxygen, SABA and prednisolone are not sufficient for an asthma attack what can be considered?

Ipratropium bromide
IV aminophylline
Magnesium sulphate

If an attack is LIFE-THREATENING: immediately give ipratropium (don't wait to see if response is poor as with severe asthma attacks)

13

Which patients are most likely to benefit from an aminophylline infusion in an asthma attack?

Those that have been taking theophylline oral

14

What is step 1 of the Asthma guidelines

When should a patient be moved on to step 2?

SABA PRN

SABAs used: salbutamol or Terbutaline

Move up if needed more than TWICE a week or woken up once per week

15

What is step 2 of the asthma guidelines ?

SABA PRN + standard dose of ICS

Recommended starting dose for adults:
400mcg beclometasone daily
Do not go over 800 mcg daily

Max of 2 drugs permitted at step 2

16

What is step 3 of the asthma guidelines? (Hint: 3 different steps involved)

1) Firstly add in a LABA (salmeterol, formoterol) to the ICS + PRN SABA

2) After addition of LABA can increase ICS dose to 800mcg daily (NB: this is not max dose, just upper end of standard dose range)

If above not worked:
3) stop LABA if no benefit, continue if some benefit

IF LABA STOPPED Consider adding:
Leukotriene receptor agonist (montelukast)
Theophylline MR
Oral MR beta agonists (e.g. Salbutamol tablets/ solution) do not use this in under 12 years

Max of 3 different drugs permitted at this stage

17

Step 4 of the asthma treatment guidelines? (4 drugs)

The patient will already be on:
SABA PRN + regular standard dose ICS
LABA

1) increase ICS to a over standard dose = regular high dose ICS

Add in a 6 week trial of one or more of:
Leukotriene receptor antagonist (montelukast)
MR theophylline
Oral MR oral beta agonist

Patient on at least 4 drugs at step 4

18

Step 5 of the asthma treatment guidelines? What 5 different drugs will the patient be on?

Add in regular corticosteroid tablets (prednisolone) refer to a respiratory specialist

Patient will be on:
PRN SABA
Regular high dose ICS
LABA
One or more of the leukotriene antagonists, theophylline MR, MR oral beta agonist
Regular prednisolone

19

Stepping down: How often should asthma treatment be reviewed?

Every 3 months

Consider reducing by up to 50% every 3 months

20

What age of child do the asthma guidelines become different?

Age 5

21

Child under 5: asthma guidelines step 1?

SABA PRN

Consider moving to step 2 if child needs SABA more than twice per week, is woken at night once a week or had an exacerbation in last 2 years (same as adult guidance)

22

Child under 5: asthma guidelines step 2?

SABA PRN
Plus standard dose regular ICS
OR MONTELUKAST (leukotriene receptor antag)

23

Child under 5: asthma guidelines step 3?

If under 2 years old REFER to specialist

SABA PRN
Plus regular standard dose ICS
Plus montelukast

24

Child under 5: asthma guidelines step 4?

Refer to specialist

25

What is standard dose ICS for adults?

Equivalent to beclometasone 400-800 mcg daily (200-400mcg BD)

26

What is standard dose ICS for children aged under 12?

200-400 mcg beclometasone daily

(100-200mcg BD)

27

What is high dose ICS for adults?

800-2000mcg daily (400-1000 mcg BD)

28

What is high dose ICS in children? What age range can high dose be used in?

400-800mcg beclometasone daily

Can only be used in 5-12 years (under 5 years cannot receive high dose ICS)

29

Which ICS is not recommend in children under 12?

Mometasone

30

What ORAL drugs used in asthma can be taken as normal in pregnancy and breast feeding? (2)

Prednisolone
Theophylline

NB: all inhaled drugs can be taken as normal too, where possible use inhaled therapy over oral therapy