Atopic Dermatitis Flashcards Preview

[OS 216] Immuno Exam 2 Carlos Cluster > Atopic Dermatitis > Flashcards

Flashcards in Atopic Dermatitis Deck (26)
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1

Refers to a predisposition to excessive IgE response

Atopic

2

Chronic relapsing skin disease is common in what age groups?

infancy and childhood

3

How many percent of children does AD affect worldwide?

10-20%

4

How many percent of children does AD occur in the first 6 months of life? first year of life? Before age 5?

45%, 60%, 85%

5

highly differentiated flattended keratinocytes

Corneocytes

6

derived from pro-fillagrin and helps maintain skin hydration

NMF

7

Encases the corneocytes preventing water loss

lipid lamellae

8

hold corneocytes together and maintain the integrity of the barrier

corneodesmosomes

9

example of a protease in the skin barrier

KLK7

10

example of a protease inhibitor in the skin barrier

cystatin A and LEKTI

11

Characteristics of the acute phase

intensely pruritic, erythematous, infiltration by Th2 cells

12

Characteristics of the chronic phase

Th1 type of response, rise in IL-12

13

Major criteria for the Hanifin-Rajka criteria

1. Pruritus
2. typical morphology and distribution
3. chronically relapsing dermatitis
4. family history

14

Minor criteria of the Hanifin-Rajka criteria

1. Anterior neck folds
2. chelitis
3. influenced by env't and emotions
4. Dennie-Morgan infraorbital folds
5. Early age of onset
6. Ichthyosis, palmar hyperlinearity, keratosis pilaris
7. immediate skin test reactivity
8. orbital darkening
9. pityriasis alba
10. elevated serum IgE
11. tendency towards recurrent cutaneous infections
12. xerosis

15

What stage of AD is being described? pruritic, erythematous papules, patches, vesicles; weeping and exudative; seen on extensor surfaces

Infant stage

16

What stage of AD is being described? large lichenified plaques and scaling, affliction of flexural folds

Adult stage

17

What stage of AD is being described? less weeping and exudative, more lichenified and excoriated, flexor surfaces affected; staph infection

Childhood stage

18

Flaking of skin early in life due to increase in penetration of anythign applied to the skin

Netherton syndrome

19

malignancy with dermatitis, presents with punched out lesions on x-ray

Letterer-Siwe disease or Langerhans histiocytosis

20

lesions on face and diaper area (acrodermatitis), chronic diarrhea and failure to thrive

Zinc deficiency

21

Wiskott-Aldrich syndrome Triad

Thrombocytopenia, Recurrent infection, Eczema

22

Top 8 Food Allergens

Milk
Egg
Peanut
Nuts
Wheat
Fish
Shellfish
Soy

23

Microbial agents that aggravate AD

S. aureus, Malassezia

24

natural antimicrobial found in the skin but congenitally defective in people with AD

Canthelecidins

25

the gold standard in treatment of AD

topical steroids

26

topical non-steroidal agent for AD

tacrolimus