Flashcards in Atopic Dermatitis Deck (26)
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1
Refers to a predisposition to excessive IgE response
Atopic
2
Chronic relapsing skin disease is common in what age groups?
infancy and childhood
3
How many percent of children does AD affect worldwide?
10-20%
4
How many percent of children does AD occur in the first 6 months of life? first year of life? Before age 5?
45%, 60%, 85%
5
highly differentiated flattended keratinocytes
Corneocytes
6
derived from pro-fillagrin and helps maintain skin hydration
NMF
7
Encases the corneocytes preventing water loss
lipid lamellae
8
hold corneocytes together and maintain the integrity of the barrier
corneodesmosomes
9
example of a protease in the skin barrier
KLK7
10
example of a protease inhibitor in the skin barrier
cystatin A and LEKTI
11
Characteristics of the acute phase
intensely pruritic, erythematous, infiltration by Th2 cells
12
Characteristics of the chronic phase
Th1 type of response, rise in IL-12
13
Major criteria for the Hanifin-Rajka criteria
1. Pruritus
2. typical morphology and distribution
3. chronically relapsing dermatitis
4. family history
14
Minor criteria of the Hanifin-Rajka criteria
1. Anterior neck folds
2. chelitis
3. influenced by env't and emotions
4. Dennie-Morgan infraorbital folds
5. Early age of onset
6. Ichthyosis, palmar hyperlinearity, keratosis pilaris
7. immediate skin test reactivity
8. orbital darkening
9. pityriasis alba
10. elevated serum IgE
11. tendency towards recurrent cutaneous infections
12. xerosis
15
What stage of AD is being described? pruritic, erythematous papules, patches, vesicles; weeping and exudative; seen on extensor surfaces
Infant stage
16
What stage of AD is being described? large lichenified plaques and scaling, affliction of flexural folds
Adult stage
17
What stage of AD is being described? less weeping and exudative, more lichenified and excoriated, flexor surfaces affected; staph infection
Childhood stage
18
Flaking of skin early in life due to increase in penetration of anythign applied to the skin
Netherton syndrome
19
malignancy with dermatitis, presents with punched out lesions on x-ray
Letterer-Siwe disease or Langerhans histiocytosis
20
lesions on face and diaper area (acrodermatitis), chronic diarrhea and failure to thrive
Zinc deficiency
21
Wiskott-Aldrich syndrome Triad
Thrombocytopenia, Recurrent infection, Eczema
22
Top 8 Food Allergens
Milk
Egg
Peanut
Nuts
Wheat
Fish
Shellfish
Soy
23
Microbial agents that aggravate AD
S. aureus, Malassezia
24
natural antimicrobial found in the skin but congenitally defective in people with AD
Canthelecidins
25
the gold standard in treatment of AD
topical steroids
26